ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The effect of anti-Igs in combination with the tumour promoter TPA on DNA and Ig synthesis in a human follicular germinal centre cell lymphoma carrying slgM and slgD was investigated. The lymphoma cells responded to both amiti-μ and anti-γ chains and to anti-δ light chains by DNA synthesis, as measured by mcthy-(3H)-thymidine incorporation. Flow cytofluorometric measurements, however, showed that only anti-μ chains induced marked increase in cytoplasmic Ig content. This result suggests that in certain B-cell subsets the signals elicited via slgM and slgD are different.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1983.tb00778.x