ISSN:
1398-9995
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
During inflammation, membrane expression of adhesion molecules and tumor necrosis factor (TNF)-receptors (TNF-R) are increased, and soluble forms of these molecules are released. This study analyzed plasma levels ofsICAM-1 and sE-selectin as well as TNF-γ, sTNF-R55, and sTNF-R75 in nonallergic (NAA) and allergic asthma patients (AA), atopic dermatitis patients (AD), and healthy children (HC) by ELISA. Plasma levels of sICAM-1. sE-selectin. and sTNF-R, but not TNF-γ, were detectable, but were not significantly different between the patient groups and healthy children. In the AA group, a significant correlation (rs0.78, P=0.008) was found between sICAM-1 and sE-selectin levels. Furthermore, a significant correlation was found between sTNF-R55 and sTNF-R75 levels in the AA group (rs=0.70, P=0.025) and in the AD group (rs=0.69, P=O.O27). In AD patients, a significant correlation was observed between sE-selectin and the disease severity, as measured by the SCORAD index (rs=0.73. P=0.038). Our data demonstrate that plasma levels of sICAM-1. sE-selectin, TNF-a, sTNF-R55, and sTNF-R75 were not different between atopic and nonatopic children during a stable phase of the disease. In AD patients, levels of sE-selectin seemed to be related to clinical severity of the disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1398-9995.1998.tb03773.x
