Electronic Resource
Oxford, UK
:
Munksgaard International Publishers
Journal of oral pathology & medicine
32 (2003), S. 0
ISSN:
1600-0714
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background: Cell-mediated immune responses in oral lichen planus (OLP) may be regulated by cytokines and their receptors.Methods: In situ cytokine expression and in vitro cytokine secretion in OLP were determined by immunohistochemistry and ELISA.Results: The majority of subepithelial and intraepithelial mononuclear cells in OLP were CD8+. In some cases, intraepithelial CD8+ cells were adjacent to degenerating keratinocytes. CD4+ cells were observed mainly in the deep lamina propria with occasional CD4+ cells close to basal keratinocytes. Mononuclear cells expressed IFN-γ in the superficial lamina propria and TNF-α adjacent to basal keratinocytes. Basal keratinocytes expressed TNF-α as a continuous band. TNF R1 was expressed by mononuclear cells and basal and suprabasal keratinocytes. There was variable expression of TGF-β1 in the subepithelial infiltrate while all intraepithelial mononuclear cells were TGF-β1−. Keratinocytes in OLP stained weakly for TGF-β1. Unstimulated OLP lesional T cells secreted IFN-γin vitro. TNF-α stimulation down-regulated IFN-γ secretion and up-regulated TNF-α secretion. IL-4, IL-10 and TGF-β1 secretion were not detected.Conclusions: These data suggest the development of a T helper 1 immune response that may promote CD8+ cytotoxic T-cell activity in OLP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-0714.2003.00077.x
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