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Digitale Medien

Inhibition of in vitro RNA synthesis by hycanthone, oxamniquine and praziquantel (1990)

Wong, L. -J. C. ; Tsao, G. -C. ; Bruce, J. I. ; [weitere]

Springer

Cellular and molecular life sciences 46 (1990), S. 461-464

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Details

ISSN: 1420-9071

Schlagwort(e): Schistosomicides ; hycanthone ; oxamniquine ; praziquantel ; RNA synthesis ; drug resistance

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The schistosomicides, hycanthone, oxamniquine and praziquantel, were found to inhibit the in vitro RNA synthesis using isolated hamster liver nuclei. Preincubation of the nuclei with these drugs revealed that the inhibitory effect of oxamniquine was irreversible and progressed with time, whereas that of hycanthone and parziquantel was reversible. On the other hand, hycanthone and praziquantel have a high affinity for DNA but oxamniquine does not. The data indicate that the mechanism of inhibition by oxamniquine is different from that of hycanthone and praziquantel.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01954230

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