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Digitale Medien

Synthesis of astatine-tagged methylene blue, a compound for fighting micrometastases and individual cells of melanoma (1998)

Norseev, Yu. V.

Springer

Journal of radioanalytical and nuclear chemistry 237 (1998), S. 155-158

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Details

ISSN: 1588-2780

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Energietechnik

Notizen: Abstract Investigation on electrophilic attaching of astatine-211 to methylene blue is carried out. Conditions for transferring astatine to a chemically active electrophilic form were found. A method for the production of astatine-211-tagged methylene blue has been developed. The resulting radiopharmaceutical preparation is free of the nonisotopic iodine carrier. The chromatographic method of purifying simultaneously the product by anion-exchange resin QAE-Sephades A-25 allows it to pass into a 0.9% solution of sodium chloride (physiological salt solution). The method provides the radiochemical yield of astatine-211-tagged methylene blue as large as 68±6%.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02386681

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