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Digitale Medien

Pharmacokinetics of an extended-release dosage form of molsidomine in patients with coronary heart disease (1985)

Ostrowski, J. ; Gaul, G. ; Voegele, D. ; [weitere]

Springer

European journal of clinical pharmacology 28 (1985), S. 611-613

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Details

ISSN: 1432-1041

Schlagwort(e): molsidomine ; angina pectoris ; pharmacokinetics ; molsidomine retard

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Molsidomine (N-carboxy-3-morpholino-sydnonimine-ethylester; Cassella-Riedel Pharma GmbH, Frankfurt/M. FRG) has an antianginal effect for up to 3–5 h after oral administration of 2 mg Corvaton [1]. Plasma levels of the parent drug can be measured during this interval. A new galenic formulation (Corvaton retard) has been developed to prolong the duration of the therapeutic action and to improve patient compliance. The present study was carried out to establish whether the in vitro dissolution profile of the tablet was reflected in vivo, thus permitting prediction of plasma molsidomine levels in patients with coronary heart disease.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00544076

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