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Digitale Medien

The chronopharmacokinetics of indomethacin suppositories in healthy volunteers (1987)

Taggart, A. J. ; McElnay, J. C. ; Kerr, B. ; [weitere]

Springer

European journal of clinical pharmacology 31 (1987), S. 617-619

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Details

ISSN: 1432-1041

Schlagwort(e): chronopharmacology ; indomethacin ; suppository ; pharmacokinetics

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The pharmacokinetics of a single 100 mg indomethacin suppository were studied in 12 healthy volunteers on two occasions at least 7 days apart. Suppositories were administered in randomised order at 9.00 and 21.00 hours to see if there was evidence of a diurnal variation in kinetic parameters. The study failed to show a significant change in single dose kinetics with the time of suppository administration. This is in contrast to previous work [1] demonstrating a circadian rhythm in the kinetics of a single oral dose of indomethacin. This suggests that the chronopharmacokinetics of indomethacin is dependent on the function of the upper gastrointestinal tract.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00606642

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