ISSN:
1440-1681
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
〈list xml:id="l1" style="custom"〉1Cardiac baroreflex sensitivity (BRS) and its sympathetic and vagal components were studied after atropine and propranolol administrations in conscious genetically hypertensive (LH), normotensive (LN) and low blood pressure (LL) rats of the Lyon strain at 5, 9, 13 and 70 weeks of age.2LH rats older than 9 weeks exhibit a lower BRS than age-matched LN and LL controls.3The vagal component of cardiac baroreflex is predominant. In LN rats, this component increases up to 9 weeks of age.4The sympathetic component of cardiac baroreflex is small and identical in the three strains and does not alter with age.5Thus, in normotensive rats, the increase in BRS during maturation reflects mainly the vagal component. The development of hypertension prevents this physiological increase in the sensitivity of the vagal component of cardiac baroreflex leading to a reduced BRS.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1440-1681.1989.tb02998.x
