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Digitale Medien

Is Lysolecithin an In Vivo Constituent of Chromaffin Granules? (1983)

Frischenschlager, Inge ; Schmidt, Wolfgang ; Winkler, Hans

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 41 (1983), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: It was recently claimed that lysolecithin (lysophosphatidylcholine) in chromaffin granules is a postmortem artefact. We have, therefore, determined catecholamine/lysolecithin ratios in adrenal tissues and isolated chromaffin granules. In rat adrenals and bovine medulla the ratios in both tissues and granules were similar. This indicates that even in rapidly frozen rat adrenal glands, sufficient lysolecithin is present in the total tissue to account for its presence in isolated organelles. Owing to the high cortex/medulla ratios such studies cannot be performed with guinea pig or rabbit adrenals. However, isolated chromaffin granules from guinea pig, in contrast to a previous study, do contain lysolecithin. We conclude that lysolecithin is an in vivo constituent of chromaffin granules of all species so far investigated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1983.tb00848.x

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