ISSN:
1365-2044
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
We compared the dose–response relationship and the neuromuscular blocking effects of mivacurium during infusions of esmolol in 40 anaesthetised rabbits. Train-of-four stimuli were applied every 10 s to the common peroneal nerve and the force of contraction of the tibialis anterior muscle was measured. Plasma cholinesterase activity decreased by 13% after esmolol infusion. The ED95 of mivacurium increased significantly from 29 (4.8) μgkg−1 with placebo to 61 (9.8) μgkg−1 during esmolol 100 μgkg−1.min−1, 49 (8.2) μgkg−1 during esmolol 300 μgkg−1.min−1 and 54 (7.3) μgkg−1 during esmolol 500 μgkg−1.min−1, respectively (p 〈 0.001). The duration of neuromuscular block with mivacurium 0.16 mgkg−1 was prolonged by 30% with esmolol due to diminished plasma cholinesterase activity (p 〈 0.05). Heart rate and mean arterial blood pressure decreased by 15% with esmolol (p 〈 0.05). The results of this study show that, in rabbits, esmolol decreased plasma cholinesterase activity, antagonised the neuromuscular blocking potency of mivacurium and prolonged its neuromuscular blocking effect.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1046/j.1365-2044.1998.00283.x
