ISSN:
0138-4988
Keywords:
Life Sciences
;
Life Sciences (general)
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
A survey is given summarizing recent insights into the causes of the genetic segregation of antibiotic-producing Streptomyces strains (plasmids, transposons, reiterated gene sequences, direct and inverted repeats). Referring to the classical regulatory models of prokaryotic operons, similar regulatory principles were shown to be involved in the secondary metabolism (pab-gene of S. griseus, brp-gene of S. hygroscopicus, afs B-gene and A-factor of S. griseus) and the known features of its control by catabolites as well. The heterogeneity of the transcriptional system (multiple promotors and holoenzymes of the RNA polymerase) is shown to constitute an essential element of the secondary metabolism accomplishing its integration into cellular cytodifferentiation.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/abio.370090406
