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A protein structural motif that bends DNA (1989)

White, Stephen W. ; Appelt, Krzysztof ; Wilson, Keith S. ; [et al.]

New York, NY : Wiley-Blackwell

Proteins: Structure, Function, and Genetics 5 (1989), S. 281-288

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Details

ISSN: 0887-3585

Keywords: Hu protein ; integration host factor ; transcription factor 1 ; DNA bending protein ; protein structure ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine

Notes: The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for thisinteraction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.

Additional Material: 3 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/prot.340050405

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