ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Mice of the RF and C57 black strains, fed an adequate diet, were donors and recipients of subcutaneous tissue implants. Abundant ceroid formed in implants of liver, heart, and adrenal. The pigment developed concurrently with degenerative changes in hepatocytes and myocardial fibers. Ceroid was intracellular in implants of adrenal gland and limited to cortical cells. Skeletal muscle and multilocular fat cells were next most productive sources of ceroid. Unilocular fat cells produced only traces. Isogeneic and allogeneic implants of corresponding tissues revealed comparable amounts of ceroid after two weeks of transplantation. Formation of pigment was correlated with the type of tissue transplanted rather than to specific host-graft responses.Implants of liver tissue were an ideal model for studying genesis of ceroid pigment. Granules of ceroid appeared first at the periphery of the implant in tissue adjacent to obviously degenerating cells of the graft. These small granules of pigment were then engulfed by macrophages. In most instances liposis preceded formation of ceroid. The presence of large amounts of lipid in the tissue at time of implantation did not augment ceroid formation. Hyper- and hypovitaminosis E, choline deficiency (to produce fatty livers), hyperestrogenism, and the administration of immunosuppressive drugs to recipients failed to influence appreciably the production of ceroid. In livers and other tissues containing little fat a relatively rapid post-implantation liposis preceded ceroid formation.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091600411
