ISSN:
0899-0042
Keywords:
NSAID
;
esterification
;
resolution
;
Candida antarctica lipase
;
rac-Indoprofen
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Lipase from Candida antarctica, commercially available immobilised on acrylic resin as Novozym® 435, allows for enantioselective esterification of rac-indoprofen (±)-1, with methanol in a dioxane-toluene solvent system. A double esterification process affords methyl ester (-)-(R)-2 in 85% e.e. and enantiopure (+)-(S)-1, both in good chemical yield. Chirality 10:321-324, 1998. © 1998 Wiley-Liss, Inc.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource