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Digitale Medien

Modulation of cartilage destruction in murine arthritis with anti-IL-1 antibodies (1993)

Loo, F. A. J. ; Arntz, O. J. ; Otterness, I. G. ; [weitere]

Springer

Inflammation research 39 (1993), S. C211

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Details

ISSN: 1420-908X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract One of the early events in murine antigen-induced arthritis is the generation of IL-1 in the inflamed joint. We investigated the role of IL-1 in the acute phase of the arthritic process by selective blockage of IL-1 bioactivity by treatment with neutralizing antibodies. Pretreatment with anti-IL-1 antibodies moderately suppressed joint swelling. The decrease in chondrocyte proteoglycan synthesis seen in the acute phase of arthritis was prevented by treatment with anti-IL-1 antibodies. IL-1 does not appear to be a major contributor to the accelerated breakdown of articular cartilage in this model. The major impact of anti-IL-1 antibodies was the prevention of proteoglycan synthesis inhibition which clearly reduced articular cartilage depletion by maintaining normal proteoglycan synthesis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01972769

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