ISSN:
1420-908X
Keywords:
Key words: Cartilage — Arthritis — Hyaluronic acid — Superoxide anion — Interleukin 1
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Objective: To examine the effect of hyaluronic acid (HA) on the induction of superoxide anion by IL-1 in chondrocytes. ¶Materials and Methods: Bovine articular chondrocytes were treated with different concentrations of IL-1. A chemiluminescent probe (L-012) was added to the medium and chemiluminescence detection was used to measure superoxide anion. ¶Results: IL-1 caused induction of superoxide anions in a dose-dependent manner. HA (10–100 〈mu〉g/ml) countered superoxide induction caused by 20 ng/ml of IL-1. ¶Conclusion: HA can afford protection against cartilage degradation, probably acting as a free-radical scavenger.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s000110050132
