ISSN:
1420-9071
Keywords:
Botulinum type A toxin
;
neuromuscular junction
;
zinc antagonism
;
depolarization dependency
;
mouse
;
Botulinum type A toxin
;
neuromuscular junction
;
zinc antagonism
;
depolarization dependency
;
mouse
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Zn2+ (10–100 μM) elevated the frequency of miniature end-plate potentials (MEPPs) in the mouse diaphragm. The effect did not depend on external Ca2+. Botulinum type A toxin (BTXA, 50 ng/ml) abolished MEPPs almost completely within 30 min. Zn2+ (100 μM) restored MEPPs and increased their frequency after they had been abolished by BTXA in Ca2+-free solutions. The antagonistic effect of Zn2+ in the Ca2+-free solution was reduced by exposing the diaphragm to the toxin in the Ca2+-free solutions containing high K+. Thus, the action of BTXA is probably enhanced by depolarization of the motor nerve terminals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01960227
