ISSN:
1432-1440
Keywords:
Fibronectin
;
Hemoperfusion
;
Drug intoxication
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Fibronectin is a glycoprotein belonging to the opsonic system and able to mediate phagocytosis by the reticuloendothelial system (RES). Severe intoxications are often followed by a diminished capacity of RES-clearance. Patients with severe drug intoxications have lower concentrations of fibronectin in plasma than healthy persons. Charcoal hemoperfusion lowers plasma fibronectin by an average of 4.7 mg/dl. Initial values below 15 mg/dl did not undergo a significant decrease in the case of hemoperfusion. Regarding these findings, determination of plasma fibronectin seems a useful parameter for monitoring RES function during treatment of drug-intoxicated patients by hemoperfusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01485029
