ISSN:
1432-0428
Keywords:
Pancreatic islets
;
insulin secretion
;
insulin content
;
glucagon secretion
;
glucagon content
;
wistar rats
;
sand rats
;
glucose
;
arginine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Isolated pancreatic islets of normoglycemic sand rats do not respond to 2.5 mM glucose with an enhanced glucagon secretion, which could be observed in normal Wistar rats. Arginine stimulates glucagon release in the presence of 2.5 mM glucose in Wistar rats as well as in sand rats. The secretion pattern is not caused by insulin deficiency since sand rat islets are characterized by an increased insulin secretion rate in vitro. This paradoxical glucagon secretion is not caused by a changed glucagon content but might be related to this species which is able to develop a diabetic syndrome spontaneously.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00422820
