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Digitale Medien

Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex (1986)

Weskamp, G. ; Lorez, H. P. ; Keller, H. H. ; [weitere]

Springer

Naunyn-Schmiedeberg's archives of pharmacology 334 (1986), S. 346-351

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Details

ISSN: 1432-1912

Schlagwort(e): Nerve growth factor (NGF) ; Rat basal forebrain ; Cholinergic neurons ; Monoaminergic neurons ; Denervation

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We have investigated whether degeneration of basal forebrain cholinergic neurons is a potential trigger for increased NGF production in the adult rat brain. Electrolytic lesions of cholinergic neurons in the septum-diagonal band and in the nucleus basalis of Meynert induced a transient increase in NGF in the ventral hippocampus (+70%) and cerebral cortex (+125%), respectively. In contrast, selective aminergic denervation of the forebrain by electrolytic lesion of the medial forebrain bundle, did not increase NGF levels in hippocampus and cerebral cortex. Thus, a cholinergic mechanism appears to regulate NGF production in adult rat basal forebrain.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00569368

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