ISSN:
1432-2072
Keywords:
Delta-sleep-inducing peptide (DSIP)
;
Paradoxical sleep (PS)
;
Phosphorylated analogue of DSIP
;
Rat
;
Sleep substance
;
Slow wave sleep (SWS)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Continued 10-h nocturnal intracerebroventricular infusion of 0.5 nmol P-DSIP, the phosphorylated analogue of delta-sleep-inducing peptide (DSIP), significantly increased slow wave sleep (22%) and paradoxical sleep (81%) in unrestrained rats. The increase in the amount of sleep was largely due to an increase in the number of sleep episodes. Larger and smaller doses were ineffective in doses ranging from 0.025 to 25 nmol. The sleep-promoting potency of P-DSIP was 5 times greater than that of DSIP compared by the same assay.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00443409