ISSN:
1432-2072
Keywords:
Haloperidol
;
Dopamine
;
Oral movements
;
Rat
;
Tardive dyskinesia
;
Homovanillic acid
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Rats with more severe orofacial movements after 51 days of haloperidol administration showed lower levels of the dopamine metabolite homovanillic acid (HVA) in the caudate compared to animals who did not develop significant mouth movements. This effect was not observed in other brain regions sampled. This finding is consistent with the hypothesis that dopaminergic receptor supersensitivity in neostriatal structures plays some role in the development of orofacial movements in rats, in association with chronic neuroleptic administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00451700