Library

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 14 (1978), S. 83-85 
    ISSN: 1432-1041
    Keywords: Propranolol ; oxprenolol ; noradrenalineduced vasoconstriction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of oxprenolol and propranolol on the venoconstrictor response to noradrenaline were studied in healthy volunteers by measuring superficial dorsal hand vein diameter at a standard congesting pressure. In 8 subjects dose response curves to noradrenaline (20–1280 ng/ml) were obtained with noradrenaline alone, with noradrenaline plus propranolol 10 µg/ml, with noradrenaline plus propranolol 10 µg/ml plus oxprenolol 3 µg/ml and with noradrenaline plus propranolol 13 µg/ml according to a double blind balanced randomised design. Propranolol 10 µg/ml significantly (P〈0.05) potentiated the vasoconstrictor response to noradrenaline and the addition of oxprenolol significantly (P〈0.05) reversed the potentiation giving a response similar to that seen with noradrenaline alone. The higher concentration of propranolol did not produce further potentiation, the response being similar to that obtained with the lower concentration of propranolol. It is suggested that the effect of oxprenolol may be attributable to alpha blocking properties, to partial beta agonism or to its membrane stabilising properties.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...