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Oral pharmacokinetics of omeprazole (1984)

Howden, C. W. ; Meredith, P. A. ; Forrest, J. A. H. ; [et al.]

Springer

European journal of clinical pharmacology 26 (1984), S. 641-643

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ISSN: 1432-1041

Keywords: omeprazole ; gastric acid secretion ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The pharmacokinetics of omeprazole were studied in a group of healthy male subjects after single and repeated oral doses of 30 and 60 mg. Absorption of omeprazole from its enteric-coated formulation was unpredictable. There was a highly significant increase in the area under the plasma concentration time curve (AUC) after repeated dosing. Omeprazole increases its own relative availability following repeated dosing. This may be due to inhibition of gastric acid secretion by omeprazole which is an acid-labile compound.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00543502

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