ISSN:
1432-1041
Keywords:
cimetidine
;
ranitidine
;
imipramine demethylation
;
desmethylimipramine hydroxilation
;
human liver microsomes
;
debrisoquine hydroxylase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of cimetidine and ranitidine on the demethylation of imipramine (IMI) and on the hydroxylation of desmethylimipramine (DMI) was studied in microsomes from four human livers. Cimetidine inhibited both demethylation of IMI and 2-hydroxylation of DMI, whilst the effect of ranitidine was not statistically significant. 2-hydroxylation of DMI is probably mediated by debrisoquine hydroxylase, a cytochrome P-450 isozyme that is monogenically controlled. The results suggest that cimetidine inhibits this enzyme.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00614311
