ISSN:
1432-1041
Keywords:
bunazosin
;
hypertension
;
alpha1-adrenoceptor blocker
;
blood pressure
;
renal blood flow
;
renal function
;
renin
;
aldosterone
;
atrial natriuretic peptide
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00637738
