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    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Autoren berichtenüber die Ergebnisse von In-vitro-Untersuchungen über die Höhe der Porphobilinogen- und der Porphyrinsynthese in menschlichen Erythrozyten mit Eisenmangel. Es zeigte sich, 1. daß die Synthese von Porphobilinogen aus δ-Aminolacvulinsäure praktisch normal ist; 2. daß in Erythrozyten mit Eisenmangel die Aminolaevulinsäure dem gleichen Stoffwechselweg folgt wie in normalen roten Blutkörperchen; 3. daß die Synthese von Porphyrin aus Porphobilinogen zum Teil gehemmt und die Menge des gebildeten Porphyrins erheblich verringert ist; 4. daß die Gabe von Eisen die Höbe der Porphyrinsynthese aus Porphobilinogen normalisiert ohne die Synthese diese Pyrolls zu stören.
    Notes: Summary The results ofin vitro studies on the rate of porphobilinogen and porphyrin synthesis in iron deficient human red blood cells are reported. It was found: 1. that the synthesis of porphobilinogen from δ-aminolaevulic acid is virtually normal; 2. that in iron deficient red blood cells δ-aminolaevulic acid follows the same metabolic paths as in normal red blood cells; 3. that the synthesis of porphyrin from porphobilinogen is partly inhibited, the amount of porphyrin formed being appreciably decreased; 4. that the administration of iron normalises the rate of porphyrin synthesis from porphobilinogen without interfering with the synthesis of this pyrrole.
    Type of Medium: Electronic Resource
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