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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 10 (1968), S. 347-355 
    ISSN: 1432-0533
    Keywords: Brain edema ; Serum protein ; Fluorescein antibody technique ; Cold lesion ; Boold-brain barrier-lesion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die histologische Verteilung der Serumproteine in normalem und ödematösen Hirngewebe wurde mit der Fluorescein-Antikörpertechnik untersucht. Hirnödem wurde bei Hunden mittels Kälteläsion nach der Methode vonKlatzo et al. erzeugt. Im normalen Gehirn war der Hauptanteil der Serumproteine auf das Gefäßlumen beschränkt und ihre Anwesenheit in Nerven-, Glia- und Endothelzellen geringfügig. Ödematöses Hirngewebe hingegen enthielt große Mengen von Serumproteinen, und zwar mehr in der weißen als in der grauen Substanz. Sie waren reichlicher in unmittelbarer Nähe der Läsion als entfernt von dieser vorhanden. In der ödematösen weißen Substanz nahe der Kälteläsion in der Hirnrinde waren die Serumproteine diffus ohne erkennbare Beziehung zu den histologischen Strukturen verteilt. In der Peripherie der ödematösen weißen Substanz waren sie netzartig verteilt, was ihre Anwesenheit im Netzwerk der Zellfortsätze anzeigen könnte. Anhäufung von Serumproteinen wurde auch in Virchow-Robinschen Raum als auch um die kleinen Gefäße beobachtet.
    Notes: Summary Histologic distribution of serum proteins within normal and edematous brain tissues was investigated with the fluorescein-antibody technique. Brain edema was produced in dogs with cold injury, as described byKlatzo et al. In normal brain large amounts of serum proteins were restricted to the vascular lumina and the presence of these proteins was sparse in nerve, glia and endothelial cells. On the other hand, edematous brain tissue contained large quantities of serum proteins; they were found in larger amounts in white than in grey matter, and were more abundant in white matter in immediate proximity to the lesion than in the area more distant from it. In the edematous white matter near the cold injury in cerebral cortex, serum proteins were distributed diffusely so that no relationship to the histological structures was noted. In the periphery of the edematous white matter they were distributed in reticular fashion, which might indicate that they are present in the net work of cell processes. Accumulation of serum proteins was also noted in the Virchow-Robin space as well as around the small vessels.
    Type of Medium: Electronic Resource
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