ISSN:
1432-0533
Keywords:
Brain tumor
;
Brain metastasis
;
Walker 256 tumor
;
Bromodeoxyuridine (BrdU)
;
Glial fibrillary acidic protein (GFAP)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To elucidate the environmental influence on the growth of a tumor, bromodeoxyuridine (BrdU) uptake in multiple tumor foci within the intracranial cavity was studied immunohistochemically with a monoclonal antibody. Walker 256 tumor implanted intracerebrally produced multifocal tumors presented as (1) intraparenchymal solid tumor, (2) tumor in the choroid plexus, and (3) leptomeningeal dissemination. The BrdU-labeling indices, or the S-phase fractions (% of nuclei labeled by BrdU divided by the number of tumor cell nuclei scored; LI), of those tumors were 48.4±1.1, 59.1±1.3, and 27.9±5.9, respectively (means ± SEM). These differences in LI, or the tumor growth activity, are discussed in relation to the different environmental conditions in different host structures. These host structure-related modification of tumor growth would be important in evaluating the proliferative activity of tumors growing at various intracranial structures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687956
