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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 84 (1992), S. 110-112 
    ISSN: 1432-0533
    Keywords: HLA-DR ; Meningioma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of HLA-DR was examined in 38 cases of meningiomas with the streptavidin-biotin immunoperoxidase method using two monoclonal antibodies to HLA-DR (LN-3 and TAL-IB5) on formalinfixed, paraffin-embedded specimens. Similar immunoreactivity was obtained with these two monoclonal antibodies. In addition to infiltrated lymphoid cells and perivascular macrophages, tumor cells themselves showed HLA-DR expression in 16 cases (42%) of meningiomas. The rate of HLA-DR-positive cases in the transitional and fibrous subtypes (64% and 67%, respectively) was higher than that in the meningotheliomatous subtype (8%). Spindle-shaped tumor cells were frequently positive for HLA-DR, whereas few of meningotheliomatous cells with plump cytoplasm were positive. Most of HLA-DR-positive cases showed no or scanty lymphoid cell infiltration, and a few cases with marked infiltration of lymphoid cells were variable for HLA-DR expression. These findings suggest little correlation between HLA-DR expression of tumor cells and the degree of lymphoid cell infiltration, but indicate an aberrant HLA-DR expression of tumor cells themselves.
    Type of Medium: Electronic Resource
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