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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 154 (1968), S. 160-169 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die vorgelegten Befunde sprechen dafür, daß bei Säuglingsmäusen durch Vacciniavirus eine spezifische Immunität gegenüber der Infektion mit Variolavirus induzierbar ist. 2. Vacciniavirus der Stämme Elstree, München-Bern und Rivers haben unterschiedliche Pathogenität für die Säuglingsmaus. Stamm Elstree ist am schwächsten pathogen, Stamm Rivers am stärksten. Stamm München-Bern hält die Mitte. 3. Die variola-protektive Wirkung der Stämme Elstree und München-Bern war etwa gleich, die des Stammes Rivers wesentlich schlechter, doch erschwert die unterschiedliche Pathogenität der Vacciniastämme für die Säuglingsmaus die Wertung der Befunde.
    Notes: Summary 1. Babymice were actively immunized with vacciniavirus. The resulting resistance to a challenge infection with variolavirus is believed to be based on a specific immunity, because a) immunization with influenzavirus resulted in no protection to a subsequent vacciniavirus infection. b) immunization with vacciniavirus resulted in no protection to a subsequent Aujeszkyvirus infection. c) 52% of vaccinia-immunized babymice survived a challenge infection with variolavirus, whereas 95% of non-immunized controls succumbed. 2. The 3 strains of vacciniavirus under test (Elstree, Munich-Bern and Rivers) differed in their virulence for babymice. Strain Elstree had the lowest virulence, strain Rivers the highest. Strain Munich-Bern was between the two. 3. The strains Elstree and Munich-Bern rendered almost equal protection to the subsequent variola challenge. The protection afforded by strain Rivers was considerably worse.
    Type of Medium: Electronic Resource
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