ISSN:
1432-1076
Keywords:
25-Hydroxyvitamin D
;
24,25-Dihydroxyvitamin D
;
Steroid-induced bone complications
;
Nephrotic syndrome
;
Relapser
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of prednisone therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)2D] was investigated in 16 children with nephrotic syndrome. These serum levels were significantly lower in patients before prednisone therapy than in age- and seasonmatched normal subjects. Patients receiving daily prednisone therapy had lower serum levels than those receiving alternateday prednisone therapy at the time when the total amounts of the steroid administered attained 1,500 or 2,000 mg/m2 of body surface area. Daily doses of 40 mg/m2 of prednisone for 3 days caused a significant decrease in serum 25(OH)D levels. Withdrawal of the steroid for 4 consecutive days was followed by a significant recovery of the serum levels. These results suggest that alternate-day prednisone therapy rather than daily treatment should be used in clinical practice to help maintain normal vitamin D metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00441145
