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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 86 (1976), S. 85-88 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach subcutaner Applikation von 0,5 mg 3,4-Benzpyren am 2. Lebenstag an Sprague-Dawley-Ratten entstanden bei 50% der Tiere nach 250±70 Tagen lokal an der Injektionsstelle Fibrosarkome. Die zusätzliche Behandlung mit immunostimulierenden Substanzen (BCG, Albumin, Vitamin A-Säure) bzw. immunodepressiv wirkenden Substanzen (Hydrocortison, Cyclophosphamid, Methotrexat), beginnend am 6. Tage nach der Geburt und durchgeführt bis zum Lebensende der Tiere, vermochte die Carcinogenese weder bezüglich der Häufigkeit der entstehenden Sarkome noch der Induktionszeit zu beeinflussen.
    Notes: Summary After subcutaneous application of 0.5 mg 3,4-benzopyrene (BP) to Sprague-Dawley-rats on the 2nd day of life, 50% of the animals developed local fibrosarcomas after 250±70 days. Additional treatment with immunostimulating (BCG, albumin, vitamin A-acid) or immunodepressive agents (hydrocortisone, cyclophosphamide, methotrexat) which was started 6 days after birth and maintained throughout life, did not influence carcinogenesis with respect to tumor incidences and induction periods of tumors.
    Type of Medium: Electronic Resource
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