ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
Soft-nanotechnologies are based upon the synthesis technologies of nanomaterials andconstruction technologies of nanostructures by life forms. They are expected as new preparationmethods for biomaterials that could be recognized as regular extracellular matrices (ECM) in ourbody by cells. We applied the soft-nanotechnology to synthesis of artificial bones made of HAp andcollagen with bone-like nanostructure and examined their physical and biological properties. Thenanocomposite obtained indicates bone-like nanostructure. Computer simulation and FT-IRsuggested that the self-organization of HAp and collagen is based on chemical interaction betweencalcium ions on HAp surface and carboxy groups on collagen. After implantation in rats and dogs,the nanocomposites are resorbed by osteoclasts followed by osteogenesis; therefore, thenanocomposites are recognized as bone in the living body. Resorption rate can be controlled bycrosslinkage. We also prepared sponge-like elastic porous body by gel-lyophilization techniqueusing additional small amount of collagen solution. Bone tissue reactions of it are the same as thenanocomposites as prepared. The nanocomposites are now in clinical research in Japan to becommercialized in near future by Pentax Co
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.49.1.pdf
