ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. The effects of adenosine, adenosine 5′-triphosphate (ATP) and inosine on pancreatic exocrine secretion were investigated in the vascularly isolated and self-hacmoperfused dog pancreas. Drugs were injected close-arterially (i.a.) in a single bolus.2. These three purine-related compounds per se did not affect resting rate of pancreatic secretion and the concentrations of protein and bicarbonate in the resting juice.3. Graded doses of adenosine (0.1–1.0 mg, i.a.) and ATP (0.1–1.0 mg, i.a.) administered 1 min prior to secretin (0.025 clinical units, i.a.) increased a secretin-stimulated secretory volume dose-dependently, and the effects of adenosine and ATP were reversed by pretreatments with theophylline (0.3 mg, i.a.).4. Insoine (1.0 mg, i.a.) affected neither secretin- nor dopamine-stimulated (3 μg, i.a.) pancreatic secretion. Adenosine and ATP did not affect dopamine-stimulated pancreatic secretion.5. These results suggest that adenosine and ATP (or terminal phosphate hydrolyzed derivatives) enhance secretin-stimulated pancreatic exocrine secretion through ‘P1’ purine receptors in the exocrine cells, without conversion to inosine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1986.tb00921.x
