Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
12 (1985), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. The effects of metoclopramide on pancreatic exocrine secretion were investigated in the pentobarbitone-anaesthetized dog. All drugs were injected into the femoral vein.2. Metoclopramide (10–1000 μg/kg) did not change the resting rate of pancreatic secretion.3. Pancreatic secretion, induced by bethanechol (3 μg/kg), was dose-dependently enhanced by simultaneous injections of metoclopramide (10 and 30 μg/kg), but the protein and bicarbonate concentrations of the pancreatic juice were not affected. Secretions induced by secretin (0.1 units/kg) and dopamine (3 μg/kg) were not modified by metoclopramide at up to 30 μg/kg.4. A larger dose of metoclopramide (1000 μg/kg) suppressed dopamine-induced secretion to a lesser extent than the same dose of sulpiride.5. From these results, it is concluded that metoclopramide enhances secretory responses to cholinergic stimulations by peripherally sensitizing the muscarinic receptor-mediated exocrine process and this drug is a weaker antagonist of the dopamine D2 receptors than sulpiride.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1985.tb00909.x
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