Library

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 17 (1983), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A B-cell subset with Fc receptors for IgA (Bα cells) has been observed in human peripheral blood. To investigate aberrations of B cells in a diseased state, the percentages of Bα cells were enumerated in peripheral blood from patients with IgA nephropathy, which is characterized by preponderant deposition of IgA-dominant immune complexes in the glomerular mesangial area. The present study showed a significant increase in Bα cells in peripheral blood from patients with IgA nephropathy but not in those with chronic proliferative glomerulo-nephritis without mesangial IgA deposition. Most FcαR-bearing cells were observed in surface IgA bearing lymphocytes. No linear correlation was observed between the levels of serum IgA and the percentages of Bα cells. The addition of aggregated IgA to cultures did not induce FcαR-bearing B cells in vitro. It is postulated that Bα cells might have some pathogenetic role in the development of IgA nephropathy and that some antigenic stimuli might play a role in the increase of peripheral blood Bα cells in patients with IgA nephropathy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...