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  • Articles: DFG German National Licenses  (6)
  • Electronic Resource  (6)
  • 2000-2004  (2)
  • 1990-1994  (4)
  • 1900-1904
  • 2002  (2)
  • 1993  (4)
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  • Articles: DFG German National Licenses  (6)
Material
  • Electronic Resource  (6)
Years
  • 2000-2004  (2)
  • 1990-1994  (4)
  • 1900-1904
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    “Living high − training low” altitude training improves sea level performance in male and female élite runners (2002)
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 12 (2002), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: Acclimatization to moderate high altitude accompanied by training at low altitude (living high–training low) has been shown to improve sea level endurance performance in accomplished, but not élite, runners. Whether élite athletes, who may be closer to the maximal structural and functional adaptive capacity of the respiratory (i.e. oxygen transport from environment to mitochondria) system, may achieve similar performance gains is unclear. To answer this question, we studied 14 élite men and eight élite women before and after 27 days of living at 2500 m while performing high-intensity training at 1250 m. The altitude sojourn began 1 week after the USA Track and Field National Championships, when the athletes were close to their season's fitness peak. Sea level 3000-m time trial performance was significantly improved by 1.1% (95% confidence limits 0.3–1.9%). One-third of the athletes achieved personal best times for the distance after the altitude training camp. The improvement in running performance was accompanied by a 3% improvement in maximal oxygen uptake (72.1 ± 1.5–74.4 ± 1.5 ml kg− 1 min− 1). Circulating erythropoietin levels were near double initial sea level values 20 h after ascent (8.5 ± 0.5–16.2 ± 1.0 IU ml−1). Soluble transferrin receptor levels were significantly elevated on the 19th day at altitude, confirming a stimulation of erythropoiesis (2.1 ± 0.7–2.5 ± 0.6 μ g ml-1). Hb concentration measured at sea level increased 1 g dl−1 over the course of the camp (13.3 ± 0.2–14.3 ± 0.2 g dl−1). We conclude that 4 weeks of acclimatization to moderate altitude, accompanied by high-intensity training at low altitude, improves sea level endurance performance even in élite runners. Both the mechanism and magnitude of the effect appear similar to that observed in less accomplished runners, even for athletes who may have achieved near maximal oxygen transport capacity for humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2002.120111_1.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial (2002)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Alverine citrate has been used in the treatment of irritable bowel syndrome for many years.Aims : To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for 12 weeks.Methods : One hundred and seven patients with irritable bowel syndrome were entered into this three-centre, double-blind, randomized, placebo-controlled, parallel group trial. The primary end-point was relief of abdominal pain indicated by improvement in the scores for severity and frequency. Secondary efficacy variables included scores for other clinical symptoms and for overall well-being.Results : The severity and frequency of abdominal pain improved in 66% and 68% of patients treated with alverine citrate vs. 58% and 69% of the placebo group, but these differences were not significant. The mean percentage reduction in the scores for abdominal pain from baseline to the final assessment, although greater in the alverine citrate group (43.7%) compared with the placebo group (33.3%), was not statistically significant.Conclusions : Alverine citrate is no better than placebo at relieving the symptoms of irritable bowel syndrome. Future trials should be designed to take into account the high and persistent placebo response seen in this condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01277.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The importance of palpation in food selection by a polyphagous grasshopper (Orthoptera: Acrididae) (1993)
    Springer
    Journal of insect behavior 6 (1993), S. 79-91 
    Details
    ISSN: 1572-8889
    Keywords: associative learning ; grasshopper ; palpation ; plant surface
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The behavioral responses of final-instar nymphs of Schistocerca americanato a variety of acceptable and unacceptable plants were recorded. Palpation occurred on all plants and the palps are involved in both acceptance and rejection. On most unacceptable plants, rejection was at first dependent on biting the leaf, but subsequently on Lantana, Machaeranthera, Moms,and Physalis,rejection often occurred after palpation of the surface alone. This is consistent with the suggestion that associative learning occurs. This response did not wane even when the insects had been without food for over 2 h. There was also some evidence of an innate response to the surface characteristics of Physalis.The features of the surfaces that produced these responses were not determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01049149
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebral intraventricular haemorrhage in a young adult (1993)
    Springer
    International journal of legal medicine 105 (1993), S. 243-245 
    Details
    ISSN: 1437-1596
    Keywords: Intraventricular haemorrhage ; Head injury ; Traumatic subarachnoid haemorrhage ; Intraventrikuläre Blutung ; Kopftrauma ; Traumatische Subarachnoidalblutung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Der Fall eines 26 Jahre alten Mannes wird beschrieben, welcher nach einer Episode von Traumen eine tödliche intraventrikuläre Hirnblutung erlitt. Bei der Obduktion wurde nach dem ersten Eindruck eine traumatische Subarachnoidalblutung vermutet, und die anfängliche Untersuchung war daher auf die Strukturen des Halses und auf die Vertebralarterien gerichtet, jedoch mit negativen Resultaten. Die Sektion des fixierten Gehirns zeigte eine massive intraventrikuläre Blutung mit sekundärer Beteiligung des Subarachnoidalraums und Ausbreitung in das Hirnparenchym. Keine Blutungsquellen oder natürliche Erkrankungen der Hirngefäße konnten gefunden werden. Die praktischen Aspekte der Diagnose und der vorsichtige Ansatz, welcher notwendig ist, um Subarachnoidalblutungen zu interpretieren, werden betont. Die Bedeutung der intraventrikulären Blutung nach Trauma ist mit der Einführung der Computertomographie offensichtlicher geworden. Die Implikationen dieses und ähnlicher Fälle werden bedacht.
    Notes: Summary A case of a 26-year-old man who suffered a fatal intraventricular cerebral haemorrhage following an episode of trauma is described. The initial appearance at necropsy suggested a traumatic subarachnoid haemorrhage and initial investigation was directed towards the anterior neck structures and the vertebral arteries with negative results. Dissection of the fixed brain showed a massive intraventricular bleed with secondary involvement of the subarachnoid space and dissection into the cerebral parenchyma. No bleeding points or natural disease of the cerebral vessels could be identified. The practical aspects of diagnosis and the cautious approach necessary in interpreting subarachnoid bleeding is emphasised. The significance of intraventricular haemorrhage following trauma has become more apparent with the advent of computed tomographic scanning. The implications for this and similar cases are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01642802
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of oximes on the dihydropyridine-sensitive Ca current of isolated guinea-pig ventricular myocytes (1993)
    Springer
    Pflügers Archiv 422 (1993), S. 325-331 
    Details
    ISSN: 1432-2013
    Keywords: Myocyte ; Voltage clamp ; Ionic currents ; Oximes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Exposure of isolated guinea-pig ventricular myocytes to the uncharged oximes 2,3 butanedionemonoxine (BDM) and norPAM (but not by the charged PAM) results in a dose-dependent reduction of the duration of the action potential. The nifedipine-sensitive Ca current is fully inhibited by BDM (IC505.8±0.4 mM) and nor PAM but is little affected by PAM. This inhibition is unaltered by the presence of BAY K 8644 but is antagonized by isoprenaline. The effect of isoprenaline is more pronounced when the solution in the patch pipette contains the non-hydrolysable analogue of adenosine 5′-triphosphate, ATPγS (the IC50 is increased to 44.0±5.2 mM). A hastening of the inactivation of the L-type Ca current persists when either 10 mM 1,2-bis(2-aminophenoxy)-ethane-N, N, N′, N-tetraacetic acid (BAPTA) or 3 mM ATPγS is present in the pipette solution or when BAY K 8644 or isoprenaline are present in the bathing fluid. These results suggest that the inhibition of the Ca current is due to the phosphatase-like activity of the oximes but differs in some respects from previous work where a reduced level of phosphorylation is achieved by the introduction of protein kinase inhibitors or protein phosphatases into the sarcoplasm in guinea-pig myocytes. These differences could be explained if Ca channel availability is regulated by at least two sites of cAMP-dependent phosphorylation with oximes able to rapidly dephosphorylate both sites, while one of these sites is not readily dephosphorylated by the endogenous phosphatases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374287
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Miticide bioassays with spider mites (Acari: Tetranychidae): effect of test method, exposure period and mortality criterion on the precision of response estimates (1993)
    Springer
    Experimental and applied acarology 17 (1993), S. 695-708 
    Details
    ISSN: 1572-9702
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Six different bioassay methods were evaluated using propargite (Omite 30% wettable powder (WP) and fenbutatin oxide (Torque 50% (WP) and 55% suspension concentrate (SC)) with twospotted spider mite, Tetranychus uriticae Koch (TSM) and European red mite, Panonychus ulmi Koch (ERM) to document their utility and precision for estimating median lethal concentrations (LC). For each method, two post-treatment exposure periods and mortality criteria were used. Post-treatment exposure period and mortality criterion had a significant influence on the precision of LC50 estimates for all tested miticides with all bioassays methods. Twenty four hour (h) post-treatment exposure was found to be the most suitable for the slide dip and Petri dish methods while 48h was the most appropriate for leaf disc methods. Scoring moribund mites as dead was the most satisfactory criterion for ensuring that biossays were as simple and precise as possible. The Petri dish residue-Potter tower method (PDR-PT) estimated the responses of TSM and ERM to propargite with high precision. The same method was not as precise for fenbutatin oxide formulations. Because significant mite run-off occurred with the leaf disc methods, their precision was not fully established. The slide dip method gave less precise estimates of LC50 values for propargite (WP) and fenbutatin oxide (WP), while the same method gave more precise LC50 estimates for fenbutatin oxide (SC) than the PDR-PT method. The toxicity of candidate miticides was found to be method-and species-dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00058509
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    Paper (German National Licenses)
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