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  • Articles: DFG German National Licenses  (7)
  • Electronic Resource  (7)
  • 1995-1999  (7)
  • 1970-1974
  • 1997  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Identification of calprotectin, a calcium binding leukocyte protein, in human dental calculus matrix (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 32 (1997), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Calprotectin is a calcium binding protein produced by leukocytes, macrophages and epithelial cells, and its levels in several tissues increase during infections and in many inflamed areas, suggesting that it may be an indicator of inflammatory activity. Osteopontin is a prominent phosphorylated glycoprotein in bone matrix, having calcium binding capacity. Recently, it has been reported that calprotectin and osteopontin are present in urinary stones (pathological mineralized masses in the body), and that these proteins may be involved in their formation. Dental calculus formed by mineralization of dental plaque is an inflammatory factor which may contribute to periodontal disease. It contains many organic components involved in mineralization. We recently found osteopontin molecules in human dental calculus and suggested that the components of its matrix may be similar to those of urinary stones. In this study, we investigated the presence of calprotectin in human dental calculus by immunohistochemical and immunoblotting analyses using a specific antibody for calprotectin. After fixation and demineralization of dental calculi adhered to tooth roots, sections embedded in paraffin were immunoreacted with the antibody for calprotectin and positive immunostaining for calprotectin was observed. Dental calculus proteins were then extracted with EDTA and separated by electrophoresis on 15% polyacrylamide gels. By immunoblotting analysis, 3 or 4 bands were observed at 11, 14.5, 22–25, 28 or 36.5 kDa and these patterns corresponded to those of calprotectin subunits. When non-immune rabbit serum was used instead of calprotectin-specific antibody as a negative control, no immunoreactivity was observed. These findings indicate that calprotectin is associated not only with antibacterial action but also with calcium binding capacity during dental calculus formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1997.tb00545.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ki -ras point mutation in different types of colorectal carcinomas in early stages (1997)
    Springer
    Diseases of the colon & rectum 40 (1997), S. 161-167 
    Details
    ISSN: 1530-0358
    Keywords: Heterogeneity ; Ki- ras [bdpoint mutation ; Colorectal carcinoma, early stage ; Tumorigenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The aim of this study was to elucidate pathways of carcinogenesis in the colon and rectum by investigating Ki-ras point mutation in different types of colorectal carcinomas in the early stage. METHODS: We analyzed rates of Ki-ras codon 12 mutations in 34 small, polypoid-type carcinomas (Tis or T1), 21 superficial-type carcinomas (Tis or T1), and 42 advanced carcinomas (T2, T3, and T4). RESULTS: Frequency of Ki-ras mutations in superficial-type carcinomas was 14.3 percent (3/21), which was significantly lower than 50 percent (17/34) in small polypoid carcinomas and 40.5 percent (17/42) in advanced carcinomas. These data suggest that another pathway of colorectal carcinogenesis that does not involve Ki-ras point mutation might exist. Among the 17 small polypoid carcinomas with Ki-ras point mutation in which both adenomatous and carcinomatous tissue were examined, 12 showed a mutation of the same type in both carcinomatous and adenomatous tissues. In two cases, mutation was present only in carcinomatous tissue and not in adenomatous tissue; in the other three cases, Ki-ras point mutation was present only in adenomatous tissue but not in carcinomatous tissue. CONCLUSIONS: These data suggest that carcinoma in a small polypoid lesion does not always develop from pre-existing adenoma with Ki-ras point mutation; in a small number of the polypoid-type early carcinomas, polyclonal composition concerning the Ki-ras gene may exist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02054981
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mutation at nucleotide position 3243 of the mitochondrial DNA as a cause of IDDM – a meta-analysis (1997)
    Springer
    Diabetologia 40 (1997), S. 1493-1494 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050856
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Factor V Leiden mutation and Japanese NIDDM (1997)
    Springer
    Diabetologia 40 (1997), S. 1363-1364 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050833
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes (1997)
    Springer
    Diabetologia 40 (1997), S. 726-730 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Vascular endothelial growth factor ; vascular permeability factor ; Goto-Kakisaki rat ; diabetic retinopathy ; ELISA ; immunohistochemistry.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. VEGF levels in ocular tissue of 6-, 12-, 18- and 28-week-old Goto-Kakizaki (GK) rats, a well-known model of non-insulin-dependent diabetes, were evaluated by highly sensitive ELISA. VEGF concentrations in the GK rat as well as in non-diabetic Wistar rat significantly decreased from the age of 6 weeks to 18 weeks. However, although VEGF concentrations in the Wistar rat continued to fall significantly from 18 to 28 weeks of age, the levels were maintained between 18 and 28 weeks of age in GK rats. Levels were significantly different between the GK and Wistar rats at 28 weeks of age. Results of immunohistochemical studies of the eyes of Wistar and GK rats at 28 weeks of age suggest diffuse distribution of this cytokine in cells of neural origin. Weak to moderate VEGF immunoreactivity was exhibited mainly in the ganglion cell layer, inner plexiform layer and inner/outer nuclear layers in rats with and without diabetes. However, in the retinal optic nerve fiber layer, retinal pigment epithelium and choroid, strong VEGF immunoreactivity was noted only in the GK rat. In conclusion, increased VEGF production in certain ocular tissue, similar to that in humans, is observed quite early, at least before the appearance of observable retinal changes in the diabetic GK rat. This also suggests that the GK rat can be used as a model of initial or latent phase diabetic retinopathy. [Diabetologia (1997) 40: 726–730]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050740
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Laparoscopic repair of a diaphragmatic hernia through the foramen of Morgagni (1997)
    Springer
    Surgical endoscopy and other interventional techniques 11 (1997), S. 668 -670 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Morgagni hernia — Abdominal wall lifting technique without pneumoperitoneum — Laparoscopy — Omentum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A 78-year-old woman is described who presented with a diaphragmatic hernia through the foramen of Morgagni. A definitive diagnosis was confirmed by a sagittal view on magnetic resonance imaging prior to surgery. The hernia was repaired laparoscopically under an abdominal wall lifting technique without pneumoperitoneum, and her symptoms completely resolved postoperatively with no evidence of recurrence. The laparoscopic repair was considered a suitable and safe procedure for the treatment of a Morgagni hernia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900418
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Fabrication of green films of single- and multi-component ceramic composites by electrophoretic deposition technique (1997)
    Springer
    Journal of materials science 32 (1997), S. 6661-6664 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract An electrophoretic technique for the formation of ceramic composites is demonstrated in the systems of biomedical hydroxyapatite–yttria-stabilized zirconia and ferroelectric barium titanate–strontium titanate. Ceramic powders show different behaviour depending on the nature of the solvent media chosen. For such purposes, a solvent mixture of acetylacetone and alcohols proved effective for adjusting the composition of deposited films.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018608605080
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    Paper (German National Licenses)
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