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  • Artikel: DFG Deutsche Nationallizenzen  (9)
  • Digitale Medien  (9)
  • 2000-2004  (4)
  • 1990-1994  (5)
Datenquelle
  • Artikel: DFG Deutsche Nationallizenzen  (9)
Materialart
  • Digitale Medien  (9)
Erscheinungszeitraum
Jahr
  • 1
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We investigated the use of measurements of serum concentrations of the cardiac proteins troponins I and T as biochemical markers of myocardial cell damage in 80 patients undergoing vascular or major orthopaedic surgery. Holter electrocardiographic monitoring was carried out before surgery and for 3 days after surgery. Blood samples for troponins I and T and creatine kinase-MB isoenzyme were taken on each of these 4 days. Outcome was assessed at 3 months using a patient questionnaire, general practitioner follow-up and case notes review. Silent postoperative myocardial ischaemia was detected in 21 patients; increases in troponins I and T and creatine kinase-MB occurred in four, six and 17 of these patients, respectively. Eight patients suffered major postoperative complications (cardiac death, myocardial ischaemia, congestive cardiac failure, unstable angina and cerebrovascular accident) and 21 minor complications (poorly controlled hypertension needing increased or new additional treatment, palpitations, increased tiredness or shortness of breath in the absence of known respiratory disease). There were no associations between postoperative ischaemia and cardiac protein concentrations. The relative odds for the associations of major adverse outcome at 3 months after surgery and postoperative ischaemia or increased serum concentrations of the three proteins were 5.39 [95% confidence intervals 1.16–27.67] for postoperative ischaemia; 5.64 [1.07–31.00] for creatine kinase-MB isoenzyme; 17.00 [2.20–116.54] for troponin T and 13.20 [1.12–135.00] for troponin I. We found troponin T to be the only prospective marker for both major and minor cardiovascular complications (relative odds 10.65 [1.26–252.88]).
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We have previously demonstrated that the peri-operative measurement of increased serum concentrations of the cardiac markers troponins I and T and creatine kinase-MB can be predictors of major cardiovascular outcomes (including cardiac death) at 3 months after surgery. In the present study, we have followed the postoperative course of 157 patients undergoing major vascular surgery or major joint arthroplasty to 1 year using a patient questionnaire, general practitioner follow-up and case-notes review. Increased postoperative marker concentrations were defined as values greater than the upper reference limit. Increases in troponin I and troponin T concentrations, as well as a single elevated creatine kinase-MB and two successively elevated creatine kinase-MB concentrations were measured in 12, 13, 33 and 15 patients respectively. Thirty-nine major adverse cardiac outcomes were recorded (cardiac death, myocardial ischaemia, congestive cardiac failure, unstable angina, cerebrovascular accident and major arrhythmias needing active treatment). There was no association between increases in any of these cardiac markers and cardiac death to 1 year. However, increases in troponin I and both a single elevated creatine kinase-MB and two successively elevated creatine kinase-MB concentrations were associated with an increased incidence of major cardiac outcomes, including cardiac death, to 1 year (odds ratio [95% confidence intervals] = 4.19 [1.16–14.87], 3.97 [1.65–9.44] and 5.19 [1.60–16.22], respectively).
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Bradford : Emerald
    British journal of clinical governance 6 (2001), S. 252-258 
    ISSN: 1466-4100
    Quelle: Emerald Fulltext Archive Database 1994-2005
    Thema: Medizin
    Notizen: Aims to measure the appropriateness of the prescribing of benzodiazepines and the effect of intervention strategies designed to improve the appropriate use of benzodiazepines. Cross-sectional data of appropriate prescribing of benzodiazepines were assessed before and after one of three intervention strategies. Appropriateness of prescribing was assessed using an algorithm based on published evidence. Hospitals were randomly allocated to receive verbal (oral communication), bulletin (paper communication) or control feedback (no communication). The change in rate of appropriate prescribing of benzodiazepines was compared between intervention groups. Gives results and concludes by highlighting areas which can be addressed to increase the impact of intervention in future studies.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Archives of environmental contamination and toxicology 26 (1994), S. 95-102 
    ISSN: 1432-0703
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Notizen: Abstract Winter flounder were captured by scuba divers from an area adjacent to a sulfite pulp and paper mill and from a reference site and the tissues examined for lesions. Severe hyperplasia of the gills, focal vacuolation in the liver, and multifocal hemosiderosis in the spleen and liver were most pronounced in large, adult fish collected near the mill. Lesions were less severe and prevalent in smaller fish. Vacuolation in the liver represents a preneoplastic lesion. The histopathological changes appear to be the result of chronic exposure. Few or no lesions were observed in the tissues of flounder taken from the reference site. Although the specific cause of these lesions is unknown, it is likely associated with cytotoxic compounds.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Archives of environmental contamination and toxicology 26 (1994), S. 491-496 
    ISSN: 1432-0703
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Notizen: Abstract This study investigated anomalies in two species of benthic sculpins (Myoxocephalus octodecemspinosus and M. scorpius) inhabiting a marine inlet in Newfoundland, Canada, where effluent from a pulp and paper mill is discharged and from two reference sites. Condition factor of both species of sculpins from the polluted and a reference site was similar. Some differences in parasite fauna were observed. Tissues from reference fish, obtained from two uncontaminated sites for comparison, were normal. Impaired vision, fin and tail necrosis, hyperplasia of the gill epithelium, depletion of energy reserves in the liver, and multifocal hemosiderosis in the spleen were observed primarily in M. octodecemspinosus captured near the paper mill. These stress-associated lesions, probably caused by undetermined xenobiotics, appear to be associated with the sediment.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 351 (1991), S. 434-434 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] SIR - Although the authors of "Bayesian reasoning in science" (Nature 350, 371; 1991) mentioned Bayes's original work, entitled "An essay towards solving a prob-lem in the doctrine of chances", they did not reference it. His original work, although rather lengthy, is available quite easily in The ...
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Archives of environmental contamination and toxicology 38 (2000), S. 197-201 
    ISSN: 1432-0703
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Notizen: Abstract. A study was conducted to determine the influence of decontamination on winter flounder living downstream from a pulp and paper mill. The fish and controls were held 8–26 weeks under contaminant-free conditions in aquaria supplied with ambient sea water. Groups of flounder, for comparison, were also sampled near the paper mill at the time of or following autopsy. No differences were apparent in length/organ-weight relationships between depurated and control groups after 26 weeks at 0–6°C, but condition factor, gonadal and hepatosomatic indices, coincident with elevated levels of detoxifying enzymes, differed from field-derived samples. Pathological changes, including hemosiderin deposits in the liver and spleen, decreased, whereas pericholangitis and clear cell foci were apparent in the depurated fish and in the field samples. In two additional groups decontaminated for 8–16 weeks at 6–16°C, there was no evidence of pericholangitis, but hemosiderin deposits persisted and an increase of fibrosis and clear cell foci occurred in contrast to the field group. These results suggest that some tissue repair in the liver transpired primarily during summer while other lesions, such as preneoplastic clear cell foci, which were probably induced prior to depuration, increased, but hemosiderin concentration remained unchanged. The latter observation is consistent with previous studies that suggest that hemosiderin concentration is not seasonally but age influenced.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of environmental contamination and toxicology 48 (1992), S. 449-456 
    ISSN: 1432-0800
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik , Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Journal of materials science 27 (1992), S. 2490-2500 
    ISSN: 1573-4803
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau
    Notizen: Abstract The physical transformation of powdered kaolinite associated with rapid dehydroxylation during flash calcination has been followed using pycnometry, thermogravimetry, electron microscopy, X-ray powder diffraction and infrared spectroscopy. 116 partially dehydroxylated kinetically-frozen calcines were produced in a laboratory flash calciner covering the following ranges of process variables: calciner temperature 700–1000 °C, rate of heating to calciner temperature 4700–15000 Ks−1, residence time at the calciner temperature 0.1–1.5 s, He or N2 calciner atmosphere. From the analyses of these calcines a picture of the changes in physical characteristics caused by flash heating of kaolinite has emerged and is described.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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