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  • 1
    ISSN: 1437-2320
    Keywords: Mannitol ; Prolongation of the tolerance in artery occlusion ; Artery occlusion ; Cerebral aneurysm ; Sequelae of aneurysm surgery ; Mannitol ; Prolongation der Toleranzzeit für Hirnarterienverschluß ; Arterienverschluß ; chirurgische Operation von Aneurysmen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aufgrund der Ergebnisse bei 384 Patienten mit Hirnaneurysmen wird die Wirkung von Mannitol für die Prolongation der Toleranzzeit des Verschlusses einer Hirnarterie diskutiert. Der chirurgische Eingriff an den Arterien wurde ausgeführt mit einem zeitweiligen Verschluß der afferenten Arterie und einer praeoperativen Gabe von Mannitol unter Normothermie und Normotension. 1. Bei den Patienten, bei denen es zu Symptomen kam oder die starben, wurden die Ursachen für die Verschlechterung untersucht. Meistens war es Vasospasmus, eine chirurgische Komplikation oder eine Infektion. Bei 4 Patienten allerdings konnte der Grund für die Verschlechterung nicht gefunden werden. Die Möglichkeit, daß diese Patienten einen Schaden durch den zeitweiligen Verschluß von Hirnarterien erlitten, konnte nicht ausgeschlossen werden. 2. Die längste Verschlußzeit bei Patienten ohne Folgen war für jede Hauptarterie 80 Minuten bei unilateralem Verschluß des A1-Abschnittes der A.cerebri anterior und 65 Minuten bei einem bilateralen Verschluß des A1-Abschnittes, 57 Minuten für den intrakranialen Verschluß der A.carotis interna, 65 Minuten bei der A.cerebri media. 3. Die chirurgischen Ergebnisse von 384 Patienten endeten mit 13 Todesfällen und einer Mortalitätsrate von 3%. Eine katamnestische Studie von 371 überlebenden Patienten nach mindestens 6 Monaten vom Tag des chirurgischen Eingriffes brachte das Ergebnis, daß 82% aller Patienten ein normales soziales Leben führen konnten.
    Notes: Summary The effect of mannitol for prolongation of the tolerance time for cerebral artery occlusion is discussed based on data in 384 patients with cerebral aneurysm. Intracranial direct surgery was performed by employing temporary occlusion of the afferent artery and preoperative administration of mannitol under normothermia and normotension. (1) In the patients who experienced sequelae or died, the causes of deterioration were studied. Most of them were due to vasospasm, surgical complication, or infection. In 4 patients, the cause of deterioration was obscure. The possibility that these patients were affected by temporary occlusion of cerebral arteries could not be ruled out. (2) The longest occlusion time in the patients without sequelae for each main artery was 80 minutes at the unilateral A1 of the anterior cerebral artery, 65 minutes at the bilateral A1, 57 minutes at the intracranial internal carotid artery and 65 minutes at the middle cerebral artery. (3) The surgical result of the 384 patients at discharge included 13 deaths, a mortality rate of 3%. Follow-up study of 371 surviving patients after at least 6 months from surgery revealed that 82% of all patients were living normal social lives.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 50 (1979), S. 259-264 
    ISSN: 0942-0940
    Keywords: Intracranial saccular aneurysm ; conservative treatment ; follow-up study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Despite our basic policy of performing intracranial definitive surgery whenever possible in cases of intracranial saccular aneurysms, we have had 80 patients with non-radically treated aneurysms. This investigation is based on an analysis of the prognosis in 54 cases where we refused definitive surgery; it provides insight into the factors and circumstances leading to the use of treatment of secondary choice, conservative rather than definitive treatment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 135 (1995), S. 163-170 
    ISSN: 0942-0940
    Keywords: Anaplastic ependymoma ; tumour suppressor gene p53
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We analyzed seven cases of anaplastic ependymoma, focusing on neuro-imaging, histopathology, and mutations of the tumour suppressor gene p53. Five of the seven tumours were supratentorial. All had both cystic and solid components, with fragment calcifications detectable on CT scan. The solid parts of the tumours were imaged as heterogenous hypo- or iso-intense areas with moderate enhancement on T1-weighted magnetic resonance images. Vascularity was not prominent on angiograms except for one case. Histologically, in addition to the WHO criteria, loss of typical cellular architecture, endothelial proliferation, and necrosis were commonly found. A mutation in Exon 5 of the tumour suppressor gene p53 was detected in one anaplastic ependymoma out of five tumours (two benign and three anaplastic ependymomas) examined by PCR-SSPC analysis of genomic DNA followed by direct sequencing. Anaplastic ependymoma typically presents as a calcified cystic tumour in the supratentorial parenchyma or transependyma. Mutations of p53 deserve further investigation to examine their possible role in the oncogenesis and malignant transformation of ependymoma.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 47 (1979), S. 37-44 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We review 36 patients with recurrent attacks before radical surgery during hospitalization and evaluate various factors which seem to contribute to the recurrence of haemorrhage.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 49 (1979), S. 87-93 
    ISSN: 0942-0940
    Keywords: Giant aneurysm ; Basilar artery ; Agenesis of internal carotid artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of a giant aneurysm, 66 mm across at its largest diameter, at the bifurcation of the basilar artery, with agenesis of the internal carotid artery, verified by angiography and autopsy, is reported.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0942-0940
    Keywords: Subarachnoid haemorrhage ; leptomeningeal cells ; arachnoid granulations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subarachnoid haemorrhage (SAH) often leads to subarachnoid fibrosis and resultant normal pressure hydrocephalus; however, how subarachnoid fibrosis occurs is unknown. We examined the changes within arachnoid granulations (AGs) and the subarachnoid space (SAS) chronologically at the parasagittal region obtained from patients with SAH at autopsy and made comparison with controls by immunostaining for cytokeratin, specific marker for leptomeningeal cells and by the elastica Masson-Goldner methods. Within a week some AGs were torn, and many inflammatory cells filled the AGs and SAS. Cytokeratin positive cells were scarce. During the next two weeks cytokeratin positive cells increased. After three weeks, AGs and SAS were filled by dense deposits of extracellular matrices surrounded by multiple layers of leptomeningeal cells.
    Type of Medium: Electronic Resource
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