ISSN:
0942-0940
Keywords:
Subarachnoid haemorrhage
;
leptomeningeal cells
;
arachnoid granulations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Subarachnoid haemorrhage (SAH) often leads to subarachnoid fibrosis and resultant normal pressure hydrocephalus; however, how subarachnoid fibrosis occurs is unknown. We examined the changes within arachnoid granulations (AGs) and the subarachnoid space (SAS) chronologically at the parasagittal region obtained from patients with SAH at autopsy and made comparison with controls by immunostaining for cytokeratin, specific marker for leptomeningeal cells and by the elastica Masson-Goldner methods. Within a week some AGs were torn, and many inflammatory cells filled the AGs and SAS. Cytokeratin positive cells were scarce. During the next two weeks cytokeratin positive cells increased. After three weeks, AGs and SAS were filled by dense deposits of extracellular matrices surrounded by multiple layers of leptomeningeal cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01411441