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  • Articles: DFG German National Licenses  (8)
  • 1980-1984  (8)
  • 1984  (3)
  • 1981  (5)
Source
  • Articles: DFG German National Licenses  (8)
Material
Years
  • 1980-1984  (8)
Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 46 (1981), S. 1077-1082 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1981), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: [14C]Acetyl-CoA was found to react spontaneously with dithiothreitol to give a relatively apolar product which was readily extractable into a butanol-toluene scintillant. This technique was used in a rapid, reproducible assay for rat brain ATP:citrate lyase using [1,5-14C]citrate as substrate. The tissue extract, a 14,000 g supernatant, exhibited a lyase activity of approximately 7 nmol acetyl-CoA produced/min per mg supernatant protein, and was inhibited ≥79% by α-ketoglutaric acid (10 mm), Cu2+ (1 mm)and Zn2+(1 mm). [14C]Oxaloacetate, [14C]malate and endogenous citrate synthase were found not to interfere significantly with lyase estimations, but NADH was required in the reaction mixture to inhibit acetyl-CoA hydrolase activity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 7 (1984), S. 13-41 
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
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    Unknown
    Oxford : Periodicals Archive Online (PAO)
    Medium aevum. 50 (1981) 301 
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 15 (1984), S. 306-327 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclosporine (CsA) is the first of a new order of pharmacological immune suppressants and represents a significant advance in the clinical control of graft rejection. In laboratory animals, its capacity to prolong allograft survival has been well documented, including reports of indefinite donor-specific immunological tolerance after shortterm CsA treatment. There is also evidence that CsA can inhibit the onset or progress of a variety of experimental autoimmune diseases. Underlying these properties of the drug is its capacity to selectively interfere with T helper cell activation and lymphokine production, although some direct effects on B cells have also been reported. In addition, sparing of suppressor cells may in part explain the mode of action of CsA which, at the molecular level, is not understood. CsA-induced nephrotoxicity in the rat has been extensively studied and is characterized by reversible proximal tubular cell damage. This problem may be aggravated by concomitant administration of other potentially nephrotoxic drugs, such as gentamicin, or by therapeutic agents which interfere with the metabolism of CsA. CsA is metabolized in the liver and excreted in the bile. Although the pathway of hepatic metabolism of CsA has not been precisely elucidated, animal studies suggest that agents capable of inducing metabolism of the drug CsA could be used to alleviate its nephrotoxic properties.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Veterinary research communications 5 (1981), S. 63-66 
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Faecal samples were collected from newly impounded stray dogs and from dogs presented to a clinic by their owners. The dogs were categorised as strays or pets and their faeces as formed or unformed. The faeces were examined bacteriologically. Campylobacters were significantly (P〈0.01) more frequently isolated from the faeces of the stray dogs but there was no significant difference between the frequency of isolation of the organism from formed or unformed faeces. The significance of this finding in relation to public health and animal health is noted.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Veterinary research communications 8 (1984), S. 303-308 
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Estimations were made of the serum isoamylase values of normal dogs and of dogs with confirmed exocrine pancreatic insufficiency. A statistically significant difference was demonstrated between the two groups in respect of the values of one of the isoamylase fractions measured. Further study has confirmed that canine salivary tissue lacks amylase activity and that the source of the isoamylase fractions was the pancreas. This knowledge has potential value in the diagnosis of canine exocrine pancreatic insufficiency.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 15 (1981), S. 867-878 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Mechanisms of corrosion at the areas of contact between screw heads and plate holes were investigated using electrochemical potential recording techniques. Static crevice corrosion was studied with plates and screws in isotonic and hypertonic saline solutions (0.9 to 7.2% NaCl). Fretting corrosion was studied in vitro with plates screwed to tubular bone analogs which were subjected to cyclic axial loads, and was studied in vivo with plates screwed on the tibia of sheep. Static tests showed that crevice corrosion does not occur in isotonic saline for periods up to one year, but can occur in hypertonic saline solutions. Dynamic loading tests demonstrated immediate potential changes which were related to the magnitude of the applied load, indicating fretting corrosion due to motion between screw head and plate, both in vitro and in vivo. A mechanism for screw-plate relative motion is proposed. It is hypothesized that corrosion seen in clinically retrieved implants due to fretting corrosion which predisposes the contact area to crevice corrosion attack.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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