ISSN:
1420-9071
Keywords:
Rat brain
;
Enolase
;
acrylamide
;
acrylamide derivatives
;
neurotoxicity
;
structure-activity relationship
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01946464
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