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  • Articles: DFG German National Licenses  (2)
  • 1985-1989  (2)
  • 1988  (1)
  • 1987  (1)
Source
  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1985-1989  (2)
Year
  • 1988  (1)
  • 1987  (1)
  • 1989  (3)
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    An adoptive immunotherapy of patients with medulloblastoma by lymphokine-activated killer cells (LAK) (1988)
    Springer
    Acta neurochirurgica 94 (1988), S. 47-52 
    Details
    ISSN: 0942-0940
    Keywords: Brain neoplasms ; medulloblastoma ; lymphokine-activated killer (LAK) cells ; adoptive immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An adoptive immunotherapy of 6 patients with medulloblastoma by lymphokine-activated killer (LAK) cells is described. They were from 2 to 9 years in age and had cerebrospinal fluid (CSF) dissemination of the tumours. All patients underwent the whole-neuraxis irradiation and chemotherapy. After the usual treatments, they were submitted to an adoptive transfer of one-haplotype identical LAK cells. The LAK cells were induced from peripheral blood lymphocytes (PBL) of their relatives with human recombinant interleukin-2 (rIL-2). 3–15×109 LAK cells were transferred intrathecally in 2–3 months. In 3 of 6 patients, neurological signs were improved and malignant cells had never been detected on CSF cytology after the adoptive immunotherapy. One among these 3 patients showed complete response in 20 months. Thus, this is an attractive approach for the treatment of medulloblastoma with CSF dissemination of the tumour which current therapeutic intervention can not cure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406615
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A fragile X female with Down syndrome (1987)
    Springer
    Human genetics 〈Berlin〉 77 (1987), S. 92-94 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Clinical and cytogenetic aspects of a female infant with trisomy 21 and the fragile X [fra (X)] chromosome are reported. Most of the facial characteristics of the patient are those observed in Down syndrome, but some features such as long face with prominent forehead and lower jaw, and large ears are related to the fra (X) syndrome. The origin of an additional chromosome 21 may be ascribed to maternal first meiotic nondisjunction in our case. It has been suspected that female carriers of the fra (X) chromosome may be predisposed to meiotic nondisjunctional events. However, there is probably no relationship between the two chromosomal abnormalities in our case because of the maternal age at the delivery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284722
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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