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  • Articles: DFG German National Licenses  (2)
  • 1990-1994  (2)
  • 1980-1984
  • 1993  (2)
  • 2-Acetamido-5-haloanisoles  (1)
  • diclofenac  (1)
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  • Articles: DFG German National Licenses  (2)
Material
Years
  • 1990-1994  (2)
  • 1980-1984
Year
  • 1993  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 124 (1993), S. 367-379 
    ISSN: 1434-4475
    Keywords: Acetylated-2-amino-5-halophenols ; 2-Acetamido-5-haloanisoles ; 6-Halo-2-methylbenzoxazoles ; 6-Halobenzoxazolones ; 6-Halotriacetylaminophenols ; 1H-NMR spectra ; Fungicidal activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wurde die Halogenierung von 2-Aminophenol-Derivaten mit N-Chlor- und N-Bromsuccinimid bei Raumtemperatur in Essigsäure untersucht. Mit den zur Verfügung stehenden Verbindungen konnte eine Neuuntersuchung der thermolytischen Umlagerung von 4-Halogenphenylaziden zu 2-Aminophenolen und anderen Produkten unternommen werden. Diese Umlagerung findet sicherlich statt, allerdings differieren die dabei beobachteten Produkte signifikant von denen, die Suschitzky et al. 1963 und 1966 beschrieben.
    Notes: Summary The halogenation of derivatives of 2-aminophenol with N-chloro- and N-bromosuccinimides at ambient temperatures in acetic acid was studied. With the necessary compounds available, a reexamination of the thermolytic rearrangement of 2-halophenyl azides to 2-aminophenols and other products was undertaken. It is certain that the rearrangement of 4-halophenyl azides to 2-aminophenols occurs but the products identified in this study differ significantly from those reported previously by Suschitzky et al. (1963, 1966).
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 38 (1993), S. 744-751 
    ISSN: 1573-2568
    Keywords: diclofenac ; hepatotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diclofenac is a frequently prescribed nonsteroidal antiinflammatory drug (NSAID). Significant hepatotoxicity related to diclofenac may be more common than previously recognized, as three patients with diclofenac-associated hepatitis were seen by one clinician in a single year. All patients were ANA positive during the hepatitis and had histologic features of chronic active hepatitis. Two had been inappropriately treated with corticosteroids. The third patient presented more acutely with jaundice and symptoms of hepatitis. Two of the patients developed the same hepatic reaction when rechallenged with diclofenac. The third patient was changed to tiaprofenic acid, a NSAID of the same family, and redeveloped evidence of hepatotoxicity. All three were subsequently able to take naproxen without liver dysfunction. Diclofenac-induced liver disease may be misdiagnosed. Twenty-six cases of significant hepatic reactions to diclofenac have been previously reported in the literature and are reviewed. Such hepatic reactions to diclofenac and related NSAIDs may be commoner than realized. Introduction of a NSAID of another class appears to be safe.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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