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  • 1
    Electronic Resource
    Electronic Resource
    Ultraviolet Absorption Spectra of Derivatives of 2,3,5- and 2,4,5-Trihydroxyacetophenone1 (1955)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 77 (1955), S. 6618-6620 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01629a061
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  • 2
    Electronic Resource
    Electronic Resource
    Glutamic Acid Metabolism in Brain and Liver during Infusion with Ammonia labelled with Nitrogen-15 (1961)
    [s.l.] : Nature Publishing Group
    Nature 189 (1961), S. 326-326 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 15N-ammonium acetate was infused into the carotid artery of cats over a period of 8-85 min. with simul taneous electroencephalographic and electrocardio-graphic tracings. The experiments were terminated by exsanguination of the animal, the blood was collected, brain and liver excised and frozen, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/189326a0
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  • 3
    Electronic Resource
    Electronic Resource
    Production of Pectic Enzymes by Phytophthora infestans (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 649-649 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] An isolate of race 4 was grown in a range of natural and synthetic media. The basal medium contained in g/1.: potassium dihydrogen phosphate, 0-5; MgSO4.7H2O, 0-25; asparagine, 1-0; yeast extract, 5-0; thiamine, 0-001, and additions were made as shown in Table 1. The pH was adjusted to 5-5 before ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211649a0
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  • 4
    Electronic Resource
    Electronic Resource
    Production of Coumarins by Phytophthora infestans (1966)
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 1165-1166 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Coumarins from blight lesions The tissue surrounding blight lesions in potato tubers of several varieties fiuoresces strongly in ultra-violet light and at least part of this fluorescence is due to an accumulation of oxygenated coumarins and their glucosides. Scopoletin (I) and scopolin ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2101165a0
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  • 5
    Electronic Resource
    Electronic Resource
    INTERACTION OF CATECHOLAMINE AND AMINO ACID METABOLISM IN BRAIN: EFFECT OF PARGYLINE AND l-DOPA (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The combination of l-DOPA and pargyline caused a decrease in level of aspartate and an increase in that of glutamine in vivo in cerebral cortex, cerebellum, brain stem, hypothalamus, neostriatum and cervical cord of rat. There was also a decreased incorporation of radioactivity from [1-14C]acetate into amino acids in vivo, most notably in cerebellum and brain stem. The labelling of glutamine was especially affected. In addition, cortical slices were prepared from guinea pigs which had been pretreated with pargyline. These slices were incubated with and without 1 mm l-DOPA in media containing [1-14C]acetate. Pargyline alone caused a stimulation of the labelling of glutamate and aspartate but not glutamine and GABA; the levels of aspartate and GABA were greater than in control slices. The addition of l-DOPA to slices from pargylinized animals caused a severe decrease in glutamine labelling but not in that of glutamate or aspartate; the level of glutamine was increased while that of glutamate was decreased. The results are discussed in terms of the known biochemical and morphological compartmentation of amino acids in brain. It is suggested that catecholamines, in the process of functioning as transmitters, may also function as metabolic regulators of other transmitters, e.g. amino acids, as well as of the energy required for balanced neuronal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb06929.x
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  • 6
    Electronic Resource
    Electronic Resource
    DECARBOXYLATION STUDIES OF GLUTAMATE, GLUTAMINE, AND ASPARTATE FROM BRAIN LABELLED WITH [1-14C] ACETATE, l-[U-14C]-ASPARTATE, AND l-[U-14C]GLUTAMATE (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Studies in vivo and in vitro of the distribution of label in C-1 of glutamate and glutamine and C-4 of aspartate in the free amino acids of brain were carried out. [1-14C]-Acetate was used both in vivo and in vitro and l-[U-14C]aspartate and l-[U-14C]glutamate were used in vitro.〈list xml:id="l1" style="custom"〉1The results obtained with labelled acetate and aspartate suggest that CO2 and a 3-carbon acid may exchange at different rates on a COa-fixing enzyme.2The apparent cycling times of both glutamate and glutamine show fast components measured in minutes and slow components measured in hours.3With [1-14C]acetate in vitro glutamine is more rapidly labelled in C-1 than is glutamate at early time points; the curves cross over at about 7 min.4The results support and extend the concept of metabolic compartmentation of amino acid metabolism in brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb06854.x
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  • 7
    Electronic Resource
    Electronic Resource
    COMPARTMENTATION OF CITRIC ACID CYCLE METABOLISM IN BRAIN: EFFECT OF AMINOOXYACETIC ACID, OUABAIN AND Ca2+ ON THE LABELLING OF GLUTAMATE, GLUTAMINE, ASPARTATE AND GABA BY [1-14C]ACETATE, [U-14C]GLUTAMATE AND [U-14C] ASPARTATE (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —(1) The effects of aminooxyacetic acid, ouabain and Ca2+ on the compartmentation of amino acid metabolism have been studied in slices of brain incubated with sodium-[1-14C]acetate, l-[U-14C]glutamate and l-[U-14C]aspartate as tracer metabolites.(2) Aminooxyacetic acid (10-3 m) inhibited the labelling of aspartate from [14C]acetate and [14C]glutamate, as well as the incorporation of label from [14C]aspartate into glutamate and glutamine. It also inhibited the labelling of GABA from all three radioactive precursors, as would be anticipated if there was inhibition of several transaminases as well as glutamate decarboxylase. The RSA of glutamine labelled from [1-14C]acetate was increased. This finding indicated that the glutamate pool which is utilized for glutamine formation is associated with glutamate dehydrogenase, and this enzyme appears to be related to the ‘synthetic tricarboxylic acid cycle’. AOAA exerted its major inhibitory effects on the citric acid‘energy cycle’with which transaminases are associated.(3) Ouabain (10-5 m) inhibited the labelling of glutamine to a much greater extent than the labelling of glutamate from [1-14C]acetate. It also caused leakage of amino acids from the tissue into the medium. Its effect on the glutamate–glutamine system was interpreted to be a selective inhibition of the 'synthetic’citric acid cycle.(4) The omission of Ca2+ from the incubation medium was associated with formation of glutamine with RSA less than 1·0 when labelled from [U-14C]glutamate, [U-14C]aspartate and lower than normal when labelled from [1-14C]acetate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1970.tb02253.x
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  • 8
    Electronic Resource
    Electronic Resource
    COMPARTMENTATION OF GLUTAMIC ACID METABOLISM IN BRAIN SLICES (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 15 (1968), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —(1) Compartmentation of glutamate metabolism in brain cortex previously observed only in vivo, has now been demonstrated in vitro.This was shown by using [U-14C]aspartate and [U-14C]glutamate as tracer substrates.(2) Preparation and maintenance of the slices at 0° resulted in reversible inhibition of glutamine synthesis. Preincubation at 37° for 10 min or preparation of the slices at room temperature partially overcame this inhibition.(3) Transfer to fresh medium after preincubation had an added stimulatory effect on glutamine synthesis.(4) Incubation in high K+ medium (27 mm) altered the relative specific activity of glutamine.(5) The data are in keeping with the postulate of the existence of at least two different pools of citric acid cycle intermediates in the cerebral cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1968.tb06184.x
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  • 9
    Electronic Resource
    Electronic Resource
    COMPARTMENTATION OF CITRIC ACID CYCLE METABOLISM IN BRAIN: LABELLING OF GLUTAMATE, GLUTAMINE, ASPARTATE AND GABA BY SEVERAL RADIOACTIVE TRACER METABOLITES (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —(1) Compartmentation of the metabolism of amino acids in brain has been studied in slices of cerebral cortex incubated with sodium [1-14C]acetate, sodium [1-14C]-bicarbonate, [1-14C]GABA or l-[1-14C]glutamate and in samples of brain after injection in vivo of [1-14C]- or [3H]acetate.(2) The method of treatment of the slices (a) maintained in ice-cold medium prior to incubation; (b) preincubation at 37°C and transfer to fresh medium affected the metabolism of the added, labelled substrate, particularly its labelling of glutamine.(3) The specific activity of glutamine labelled from the above metabolites was greater than that of glutamic acid in experiments of 10–30 minutes duration, whether or not subjected to pretreatment in the cold.(4) Incubation in medium containing 27 mm-K+ was associated with a decrease in the relative specific activity (RSA) of glutamine, except for the increase when l-[1-14C]glutamate was the precursor.(5) The data have been discussed in terms of metabolic compartmentation and their consistency with the concept of the presence in brain of more than one citric acid cycle, one containing the relatively smaller pools of intermediates and associated with synthetic processes; the other containing the relatively larger pools of intermediates and functioning as a homeostatic buffer for energy metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1970.tb02254.x
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  • 10
    Electronic Resource
    Electronic Resource
    QUANTITATIVE ASPECTS OF CO2 FIXATION IN MAMMALIAN BRAIN IN VIVO (1964)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 11 (1964), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1964.tb06117.x
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