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  • Articles: DFG German National Licenses  (4)
  • 1990-1994  (4)
  • 1994  (4)
  • 1
    Electronic Resource
    Electronic Resource
    “The” pheochromocytoma: A benign, intra-adrenal, hypertensive, sporadic unilateral tumor. Does it exist? (1994)
    Springer
    World journal of surgery 18 (1994), S. 467-472 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le but de cette étude a été d'évaluer la fréquence du phéochromocytomes (pheo), défini par l'étiquette historique de “tumeur bénigne sporadique, localisé dans la surrénale, responsable d'hypertension”. Trois séries importantes, comprenant 310 tumeurs comportant des tissus chromaffines sous-phréniques, opérées pendant des périodes de 17, 23, et 41 ans, ont été revues. Parmi celles-ci, 48 (15.5%) étaient malignes, i.e. métastatiques, et 262 (84.5%) étaient bénignes, 42 (13.5%) étaient ectopiques (35% des tumeurs malignes vs 9.5% des tumeurs bénignes), 230 (74.2%) étaient responsables d'hypertension, (74% des tumeurs bénignes vs 73% des tumeurs malignes), 29 (9.4%) étaient bilatérales, parmi lesquelles 23 étaient des tumeurs familiales. Quarante et une (13.2%) avaient un syndrome MEN II A ou B, 20 (6.5%) étaient associées avec une phacomatose. D'autres avaient des antécédents familiaux de phéo non MEN (n=5) ou d'hyperparathyroïdie apparemment sporadique (n=4) ou d'autres tumeurs neuro-endocrines (n=9). Toutes caractéristiques confondues, et parfois combinées, 125 (40.3%) seulement avaient une description classique, 47% au moment de la présentation, et seulement 40.3% à la fin du suivi. La survenue de métastases ou le diagnostic de maladie familiale métachrone sont des arguments pour rendre la surveillance obligatoire la vie durant. Dans certains cas, des études génétiques sont souhaitables.
    Abstract: Resumen Este estudio busca verificar la frecuencia del feocromocitoma, el cual ha sido definido históricamente como un “tumor unilateral benigno, intra-adrenal, hipertensivo y esporádico”; tres voluminosas series que comprenden 310 tumores cromafínicos subfrénicos operados durante 17, 23 y 41 años, respectivamente, han sido revisadas. Entre los 310 feocromocitomas, 48 (15.5%) eran malignos, o sea metastásicos, y 262 (84.5%) benignos; 42 (13.5%) fueron ectópicos (35% de los malignos vs. 9.5% de los benignos); 230 (74.2%) eran hipertensivos (74% de los benignos vs. 73% de los malignos); 29 (9.4%) fueron bilaterales, incluyendo 23 con historia familiar positiva; 41 (13.2%) tenían síndrome NEM II A o B y 20 (6.5%) se presentaron en un cuadro de facomatosis. Algunos presentaban una historia familiar de feocromocitoma no-NEM (5 casos) o hiperparatiroidismo aparentemente esporádico (4 casos) u otros tumores neuroendocrinos (9 casos). Algunas de estas caracteristicas aparecían posiblemente combinadas; finalmente 125 (40.3%) casos solamente se ajustaban a la descripción clásica del tumor, 47% en el momento de su presentación inicial y 40.3% sólo al final del período de seguimiento. El hecho de que se presenten metástasis o el diagnósitico metacrónico de enfermedad familiar hace obligatorio el seguimiento a largo plazo. Los estudios genéticos pueden estar indicados en pacientes con feocromocitoma.
    Notes: Abstract This study aims to examine the frequency of the pheochromocytoma (pheo), defined as a “benign, intra-adrenal, hypertensive, sporadic, unilateral tumor.” Three large series amounting to 310 subphrenic chromaffin tumors operated over periods of 17, 23, and 41 years, respectively, have been reviewed. Among those combined 310 pheos, 48 (15.5%) were malignant (i.e., metastatic) and 262 (84.5%) were benign; 42 (13.5%) were ectopic (35% of malignant tumors versus 9.5% of benign tumors); 230 (74.2%) were hypertensive (74% of benign tumors versus 73% of malignant tumors); 29 (9.4%) were bilateral, including 23 patients with a family history; 41 (13.2%) of patients had MEN II type A or B syndrome; and 20 (6.5%) occurred in a phacomatosis setting. Some of the patients had a non-MEN family history of pheo (n=5), seemingly sporadic hyperparathyroidism (n=4), or other associated neuroendocrine tumor (n=9). Sometimes several of these features were combined. Finally 125 (40.3%) cases fitted the classic description of the tumor, 47.0% at the time of initial presentation and 40.3% at the end of follow-up. Late occurrence of metastases or metachronous diagnosis of familial disease make lifelong follow-up mandatory. Genetic studies may be indicated in pheochromocytoma patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00353738
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  • 2
    Electronic Resource
    Electronic Resource
    Umsetzung von Isothiocyanaten und Isonitrilen mit R2Al-AlR2 [R = CH(SiMe3)2]; ein- und zweifache Insertion von Isonitril in die Aluminium-Aluminium-Bindung (1994)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 127 (1994), S. 1587-1592 
    Details
    ISSN: 0009-2940
    Keywords: Al-Al bond ; insertion of isonitriles ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of Isothiocyanates and Isonitriles with R2Al-AlR2 [R = CH(SiMe3)2]; Single and Double Insertion of Isonitrile into the Al-Al BondTetrakis[bis(trimethylsilyl)methyl]dialuminium(4) 1 reacts with phenyl or tert-butyl isothiocyanate with cleavage of the C = S double bond. Two compounds are formed: R2Al-S-AlR2 [R = CH(SiMe3)2] 3 and R2Al-C(NR')-AlR2 (4 R' = C6H5; 5 R'= CMe3) with a sulfur atom or an isonitrile group inserted between the aluminium atoms. Compounds 4 and 5 were isolated in high yield by the reaction of 1 with the appropriate isonitriles. By using an excess of phenyl isonitrile a dark red compound 6 is obtained with two isonitrile units inserted into the Al-Al bond and formation of a C-C single bond. According to crystal structure determinations of 4 and 6 a three-membered heterocycle is formed by the interaction of the nitrogen lone-pair to one of the Al atoms in 4, while in 6 both Al atoms are four-coordinated by bonding to a nitrogen and a carbon atom with formation of two across the C-C bond anellated four-membered heterocycles. As shown by NMR spectroscopy the molecular structure of 4 with one stereochemically saturated and one unsaturated Al atom is unchanged in solution even upon heating to 100°C.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19941270906
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  • 3
    Electronic Resource
    Electronic Resource
    Phosphaniminato-Komplexe des Schwefels. Synthese und Kristallstrukturen von [SO(Cl)(NPPh3)], [SO2(Cl)(NPPh3)] und [SCl(NPPh3)2]ClProfessor Egon Uhlig zum 65. Geburtstag gewidmet (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 620 (1994), S. 1986-1991 
    Details
    ISSN: 0044-2313
    Keywords: Phosphorane Iminato Complexes of Sulfur ; Syntheses ; IR Spectra ; Crystal Structures ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Phosphorane Iminato Complexes of Sulfur. Synthesis and Crystal Structures of [SO(Cl)(NPPh3)], [SO2(Cl)(NPPh3)], and [SCl(NPPh3)2]ClThe title compounds have been prepared by the reaction of Me3SiNPPh3 with SOCl2, SO2Cl2, and SCl2, respectively. They form colourless, moisture sensitive crystals, which were characterized by IR spectroscopy and by crystal structure determinations.[SO(Cl)(NPPh3)]: Space group P21/n, Z = 4, structure determination with 2 434 observed unique reflections, R = 0.047. Lattice dimensions at 19°C: a = 1 304.8, b = 996.5, c = 1 339.5 pm, β = 93.75°. The compound forms monomeric molecules with a remarkably long S—Cl bond of 234.2 pm and distances SN and PN of 154.6 and 161.6 pm, respectively, which agree with double bonds.[SO2(Cl)(NPPh3)]: Space group P21/n, Z = 4, structure solution with 2 872 observed, unique reflections, R = 0.047. Lattice dimensions at 20°C: a = 956.9, b = 1 909, c = 1 002.0 pm, β = 106.06°. The compound forms monomeric molecules with distances S—Cl of 207.1 pm, SN of 154.5 pm, and PN of 161.6 pm.[SCl(NPPh3)2]Cl: Space group P21/c, Z = 4, structure solution with 5 224 observed, unique reflections, R = 0.042. Lattice dimensions at 20°C: a = 1 108.6, b = 1 603.8, c = 1 840.5 pm, β = 99.98°. The compound forms ions [SCl(NPPh3)2]+ and Cl-. In the cation the sulfur atom is ϕ-tetrahedrally coordinated with a long S—Cl distance of 248.5 pm and SN bond lengths of 154.5 and 156.0 pm.
    Notes: Die Titelverbindungen entstehen durch Umsetzung von Me3SiNPPh3 mit Thionylchlorid, Sulfurylchlorid bzw. Schwefeldichlorid als farblose, feuchtigkeitsempfindliche Kristalle, die wir durch die IR-Spektren und durch Kristallstrukturanalysen charakterisiert haben.[SO(Cl)(NPPh3)]: Raumgruppe P21/n, Z = 4, Strukturlösung mit 2 434 unabhängigen beobachteten Reflexen, R = 0,047. Gitterabmessungen bei 19°C: a = 1 304,8; b = 996,5; c = 1 339,5 pm, β = 93,75°. Die Verbindung bildet monomere Moleküle mit einer auffällig langen S—Cl-Bindung von 234,2 pm und Abständen SN und PN von 154,6 bzw. 161,6 pm, die Doppelbindungen entsprechen.[SO2(Cl)(NPPh3)]: Raumgruppe P21/n, Z = 4, Strukturlösung mit 2 872 unabhängigen beobachteten Reflexen, R = 0,047. Gitterabmessungen bei 20°C: a = 956,9; b = 1 909; c = 1 002,0 pm, β = 106,06°. Die Verbindung bildet monomere Moleküle mit Abständen S—Cl von 207,1 pm, SN von 154,5 pm und PN von 161,6 pm.[SCl(NPPh3)2]Cl: Raumgruppe P21/c, Z = 4, Strukturlösung mit 5 224 unabhängigen beobachteten Reflexen, R = 0,042. Gitterabmessungen bei 20°C: a = 1 108,6; b = 1 603,8; c = 1 840,5 pm, β = 99,98°. Die Verbindung bildet Ionen [SCl(NPPh3)2]+ und Cl-. Im Kation ist das Schwefelatom ϕ-tetraedrisch koordiniert mit einem langen S—Cl-Abstand von 248,5 pm und SN-Bindungslängen von 154,5 und 156,0 pm.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19946201125
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  • 4
    Electronic Resource
    Electronic Resource
    Die Reaktion des [(Me3Si)2CH]2Al—CH2—Al [CH(SiMe3)2]2 mit LiCH(PMe2)2; Bildung eines fünfgliedrigen Al2C2P-Heterozyklus (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 620 (1994), S. 1427-1433 
    Details
    ISSN: 0044-2313
    Keywords: Methylene bridged dialuminium compounds ; reaction with LiCH(PMe2)2 ; Al2C2P heterocycle ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Reaction of [(Me3Si)2CH]2Al—CH2—Al [CH(SiMe3)2]2 with LiCH(PMe2)2; Formation of a Five-membered Al2C2P HeterocycleThe recently synthesized methylene bridged dialuminium compound [(Me3Si)2CH]2Al—CH2—Al [CH(SiMe3)2]2 3 reacts with one equivalent of LiCH(PMe2)2 in the presence of TMEDA to give an adduct with one aluminium atom coordinated by the carbanionic carbon atom and the second one coordinated by one phosphorus atom. A five-membered heterocycle 5 is formed, which was characterized by a crystal structure determination showing a strongly bent ring with the phosphorus atom located above the plane of the four remaining atoms (Al2C2). 5 is unstable in ethereal solution decomposing under ether cleavage to the educt 3 and the diphosphinomethane derivative CH2(PMe2)2.
    Notes: Die methylenverbrückte Dialuminiumverbindung [(Me3Si)2CH]2Al—CH2—Al [CH(SiMe3)2]2 3 reagiert mit einem Äquivalent LiCH(PMe2)2 in Gegenwart von TMEDA unter Anlagerung des carbanionischen Kohlenstoffatoms und eines der beiden Phosphoratome an seine beiden ungesättigten Metallatome. Dadurch entsteht ein fünfgliedriger Al2C2P-Heterozyklus 5, der im Festkörper eine sehr starke Winkelung aufweist. 5 ist in etherischer Lösung nicht beständig und ergibt unter Etherspaltung neben dem Edukt 3 das Diphosphanomethan CH2(PMe2)2.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19946200818
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