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  • Articles: DFG German National Licenses  (3)
  • 2005-2009  (1)
  • 1985-1989  (2)
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  • Articles: DFG German National Licenses  (3)
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Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Demonstration of donor specific unresponsiveness in rat islet allografts: importance of transplant site for induction by cyclosporin A and maintenance (1989)
    Springer
    Diabetologia 32 (1989), S. 779-785 
    Details
    ISSN: 1432-0428
    Keywords: Islet transplantation ; cyclosporin A ; allograft ; tolerance induction ; transplant site
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to evaluate the effects of transplant site (the liver via the portal vein vs the renal subcapsular space) on islet allograft survival using cyclosporin A and also to determine whether or not the unresponsiveness obtained is donor specific and how the site selected is related to the maintenance of unresponsiveness. Prolongation of islet allograft survival (WKA/Qdj:RT1u→ Lewis:RT11) was obtained by using hand-picked clean fresh islets as donors and by s. c. administration of cyclosporin A (30 mg/kg, day 0, 1, 2) when the islets were transplanted into the liver. Eleven out of 15 recipients were normoglycaemic for more than 90 days after transplantation (control mean survival time: 4.4±1.1 days, n=5). However, all the renal subcapsular grafts were rejected within 18 days after transplantation. Two normoglycaemic recipients bearing intrahepatic grafts were challenged with full-thickness donor-strain (WKA/Qdj) skin grafts at 120 days after the islet transplantation. Both recipients became diabetic and the skin grafts rejected within 16 days. The nine normoglycaemic recipients were made diabetic again with streptozotocin (40 mg/kg) between 90 and 120 days after the initial islet transplantation. Re-transplants of fresh donor-strain (WKA/Qdj) islets into the liver (n=3) in the absence of cyclosporin A maintained normoglycaemia in the recipients for more than 60 days, whereas re-transplants of donor-strain islets beneath the kidney capsule were rejected within 20 days. Intrahepatic re-transplants of third party grafts (PVG/c: RT1c:) (n=3) were rejected after seven days. These findings clearly demonstrate that the donor specific unresponsiveness in rat islet allografts was not only induced but also maintained only when the liver was the site used for implantation of the islets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00264907
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Prenatal DNA analysis in four embryos/fetuses at risk of 21-hydroxylase deficiency (1988)
    Springer
    European journal of pediatrics 148 (1988), S. 228-232 
    Details
    ISSN: 1432-1076
    Keywords: Prenatal diagnosis ; 21-hydroxylase deficiency ; DNA analysis ; HLA typing ; Chorionic villus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prentatal diagnosis of 21-hydroxylase deficiency (21-OHD) in two unrelated embryos and two fetuses was attempted with the Southern hybridization method using the 21-hydroxylase (21-OHase) complementary DNA as a probe. The two embryos whose genomic DNA was extracted from their chorionic vili both had four TaqI fragments (3.7 kb, 3.2 kb, 2.4 kb and 2.3 kb) identical to those of their respective parents and normal controls, while the DNA from each proband of these two families lacked with the 3.7 kb and the 2.3 kb fragments corresponding to the functional 21-OHase gene (21-OHase B gene). These findings indicated that none of the embryos examined were deletion homozygotes for the 21-OHase B gene. In the two fetuses, only amniotic fluid cells were available for prenatal diagnosis. The results of Southern hybridization analysis were uninformative since all family members, including the probands and fetuses, had all four TaqI fragments. Linkage studies between 21-OHD and human leukocyte antigen (HLA) haplotypes and those between the disease and restriction fragment length polymorphisms of the 4th complement gene revealed that the fetus of one family was normal. The other fetus could not be diagnosed because a recombination between the class I HLA and the 21-OHD loci had occurred in this family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441409
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Boss Forming, An Environment-Friendly Rotary Forming (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 344 (July 2007), p. 947-953 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Boss forming, which is sometimes called hub forming, has attracted its attention as anenvironment-friendly rotary forming process to form a circular plate with a hole into a boss shape.An experimental study was conducted to survey the technological possibility of boss forming. Bossforming of A1050-O commercially pure aluminum plate of 10 mm thickness was carried out atroom temperature under various working conditions. The effects of the working conditions on themetal flow in boss forming were clarified experimentally
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.344.947.pdf
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    Paper (German National Licenses)
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