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  • Articles: DFG German National Licenses  (21)
  • 2005-2009  (9)
  • 1985-1989  (12)
  • 1
    Electronic Resource
    Electronic Resource
    Clinical profiles of vitiligo in China: an analysis of 3742 patients (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Very few articles have aimed to illuminate the clinical profiles of vitiligo in China. We conducted this retrospective survey involving 4118 outpatients with vitiligo in order to identify the differences among various clinical types of vitiligo and their associated disorders. Completed questionnaires (3742) were validated and analysed. Of this large cohort, 1565 (41.8%) individuals presented vitiligo vulgaris, followed by focal, segmental, acrofacial, and universal, in that order. The mean age of vitiligo onset was 18.88 years. More than 60% of the patients were affected before 20 years of age. Patients with segmental vitiligo were affected earlier than those with other types of vitiligo (15.55 years; (P 〈 0.001). More than 74% of the patients presented with focal vitiligo at onset. After 3–5 years, 99% of active vitiligo was worse and shifted from one clinical type to another. However, there was no transformation between acrofacial vitiligo and segmental vitiligo. Compared with the general population, the patients with vitiligo were more likely to be affected by rheumatoid arthritis (P 〈 0.01), ichthyosis (P 〈 0.01), chronic urticaria (P 〈 0.01), or alopecia areata (P 〈 0.01).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2005.01813.x
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of boron on the deep donors (DX centers) in GaAs:Si (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 54 (1989), S. 1344-1346 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We found that, when boron was introduced into GaAs:Si, the deep donors induced by pressure exceeding 20 kbar reported previously by M. Mizuta, M. Tachikawa, H. Kukimoto, and S. Minomura [J. Appl. Phys. 24, L143 (1985)] disappeared while new donor levels with reduced binding energies and capture barrier heights appeared. It is proposed that B atoms paired up with Si donor atoms and the resultant change in the short-range potential of the Si donor atoms depressed the capture barrier height of the pressure-induced deep donor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.100710
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  • 3
    Electronic Resource
    Electronic Resource
    Lattice relaxation of pressure-induced deep centers in GaAs:Si (1987)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 51 (1987), S. 349-351 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Deep centers induced by hydrostatic pressure in GaAs:Si have been studied by deep level transient spectroscopy and constant temperature capacitance transient techniques. The capture behavior of these centers has been studied in detail and found to be consistent with the multiphonon emission theory. The pressure coefficients of the ionization energy and the barrier height are consistent with the large lattice relaxation model proposed by D. V. Lang and R. A. Logan [Phys. Rev. Lett. 39, 635 (1977)].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.98437
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  • 4
    Electronic Resource
    Electronic Resource
    Pressure dependence of the DX center in Ga1−xAlxAs:Te in the vicinity of the Γ-X crossover (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 1195-1197 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The pressure dependence of the DX center in Ga1−xAlxAs :Te has been studied in two samples with x=0.15 and 0.35, respectively. The pressure coefficients of the activation energies for both emission and capture were found to change sign when the band gap of GaAlAs changes from direct to indirect. These results, together with previous experiments, suggested that electrons can be emitted from and capture into the DX centers via both L and X valleys.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.100017
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  • 5
    Electronic Resource
    Electronic Resource
    Pressure dependence of Schottky barrier height at the Pt/GaAs interface (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 974-976 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The Schottky barrier height at the Pt/GaAs interface has been measured as a function of pressure using a diamond anvil cell. The Schottky barrier height was found to shift to higher energy with a linear pressure coefficient of 11 meV/kbar, which is equal to the pressure coefficient of the fundamental gap of GaAs and with a nonlinear coefficient of −0.26 meV/kbar2. These results are discussed in terms of defect models which have been proposed to explain the Fermi level pinning in Schottky barriers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.100045
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  • 6
    Electronic Resource
    Electronic Resource
    Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-κB (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Prominent infiltration of eosinophils into the airway mucosa and release of inflammatory mediators upon their adhesion onto airway epithelial cells are the immunopathogical mechanisms of allergic asthma.Objective:  We investigated the effect of normal and paraformaldyhyde-fixed human eosinophils on BEAS-2B cells, a human bronchial epithelial cell line, for the release of inflammatory cytokine interleukin (IL)-6.Methods:  Interleukin-6 in cell culture supernatant, protein amount of p38 mitogen-activated protein kinase (MAPK), and nuclear factor-κB (NF-κB) activity in BEAS-2B cells were analyzed by Western blot and enzyme-linked immunosorbent assay (ELISA). IL-6 gene expression was assessed by reverse transcriptase-polymerase chain reaction (RT-PCR), and p38 MAPK activity and inhibitor (I)κB-α induction were evaluated by Western blot.Results:  Co-culture of BEAS-2B cells and eosinophils induced a significant elevation of IL-6 expression in BEAS-2B cells. Interaction of eosinophils and BEAS-2B cells led to a marked induction in phospho-p38 MAPK, phospho-IκB-α and activity of NF-κB in BEAS-2B cells. NF-κB inhibitor BAY 11-7082 and p38 MAPK inhibitor SB 203580 significantly decreased IL-6 release in a co-culture of BEAS-2B cells and eosinophils. Fixed human eosinophils were able to maintain their ability to induce IL-6 release in co-culture, activate p38 MAPK and NK-κB, and up-regulate IL-6 gene expression in BEAS-2B cells.Conclusions:  These data indicate that the interaction of eosinophils and bronchial epithelial cells plays an important role in airway inflammation, at least partly, via IL-6 induction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00884.x
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  • 7
    Electronic Resource
    Electronic Resource
    Discovery of a new photoinduced electron trap state shallower than the DX center in Si doped AlxGa1−xAs (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 66 (1989), S. 5632-5634 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have found a new electron trap state in Si-doped AlxGa1−xAs by deep level transient spectroscopy and constant temperature capacitance transient measurements under strong light illumination. This new trap is shallower than the DX center associated with Si impurity in that its emission and capture activation energies are equal to 0.20±0.05 and 0.17±0.05 eV, respectively. Its maximum concentration is comparable to the concentration of the DX center. Possible origins of this new trap and its relationship to the DX center are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.343672
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  • 8
    Electronic Resource
    Electronic Resource
    Regulation of Homer and group I metabotropic glutamate receptors by nicotine (2005)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 21 (2005), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The present study focuses on the nicotine-induced modulation of mRNA and protein expression of a number of genes involved in glutamatergic synaptic transmission in rat brain over different time periods of exposure. A subchronic (3 days) but not the chronic (7 or 14 days) administration of nicotine resulted in the up-regulation of Homer2a/b mRNA in the amygdala while in the ventral tegmental area (VTA) no change in expression of either Homer2a/b or Homer1b/c was observed. Although the increase in Homer2a/b mRNA was not translated into the protein level in the amygdala, a slight but significant up-regulation of Homer1b/c protein was observed in the same region at day 3. Both Homer forms were up-regulated at the protein level in the VTA at day 3. In the nucleus accumbens, 14 days of nicotine treatment up-regulated mRNA of Homer2b/c by 68.2% (P 〈 0.05), while the short form Homer1a gene was down-regulated by 65.0% at day 3 (P 〈 0.05). In regard to other components of the glutamatergic signalling, we identified an acute and intermittent increase in the mRNA and protein levels of mGluR1 and mGluR5 in the amygdala. In the VTA, however, the effects of nicotine on mGluR mRNA expression were long-lasting but rather specific to mGluR1. Nevertheless, mGluR1 protein levels in the VTA area were up-regulated only at day 3, as in the amygdala. These data provide further evidence for the involvement of nicotine in the glutamatergic neuronal synaptic activity in vivo, suggesting a role for the newly identified Homer proteins in this paradigm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.2005.03945.x
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  • 9
    Electronic Resource
    Electronic Resource
    Hyaline Cell-Rich Chondroid Syringoma- Report of Two Cases. (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Case 1: A 38 year-old man presented with a painless right post auricular mass, slowly growing for ten years. Clinical impression was a salivary gland lesion. The excised mass measured 3 cm and was gelatinous. Case 2: A 28 year-old man presented with a lump in the region of the left heel, slowly growing for several years. Excision revealed a lobulated pink-gray mass measuring 2 cm. In both cases, histology demonstrated a circumscribed encapsulated proliferation of tumour cells surrounded by abundant myxoid stroma. There were almost exclusively hyaline cells with plasmacytoid features, arranged predominantly in nests and sheets with abundant pink cytoplasm and hyaline inclusions. Round to oval nuclei with occasional small nucleoli and rare mitotic figures were seen. Both cases stained strongly positive for low molecular weight cytokeratin, S 100 and vimentin and were negative for desmin, smooth-muscle actin and muscle-specific actin. We describe two cases of hyaline cell-rich chondroid syringoma, a histologically benign entity. The importance in recognizing this entity is that these tumors can easily be confused with malignant neoplasms including malignant melanoma, myxoid chondrosarcoma and alveolar soft part sarcoma. Follow up for a year has shown no evidence of metastases or recurrence in both cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320hl.x
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  • 10
    Electronic Resource
    Electronic Resource
    Isolation of a picorna-like virus from smelt, Osmerus mordax (Mitchill) (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 11 (1988), S. 0 
    Details
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2761.1988.tb00537.x
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